New quinazolinone-based Mannich bases: Synthesis and in vitro cytotoxic evaluation
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Title |
New quinazolinone-based Mannich bases: Synthesis and in vitro cytotoxic evaluation
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Creator |
Minh, Nguyen Van
Thao, Nguyen Thi Phuong Linh, Nguyen Pham Duy Vu, Tran Khac |
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Subject |
Cancer
Mannich Cytotoxicity Quinazolinone |
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Description |
244-250
This research presents the synthesis of new quinazolinone-based Mannich bases in good yields via a three-step procedure. The first step is the reaction of 6-hydroxyanthranilic acid 1 with an excess of acetic anhydride at 150°C for 2 h to afford benzoxazinone 2 in 87% yield. Compound 2 is then reacted with 4-aminophenol in DMSO at reflux for 7 h to give compound 3 in 75% yield. Finally, the reaction of 3 with paraformadehyde and secondary amines in ethanol affords new quinazolinone-based Mannich bases 4a-c and 5a-e in 55-70% yields. The structure of Mannich bases have been characterized by NMR and MS spectra. The bio-assay results show that some new Mannich bases exhibited weak to moderate cytotoxic activity against SKLu-1 and MCF-7 cell lines. |
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Date |
2023-03-17T07:19:19Z
2023-03-17T07:19:19Z 2023-03 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61536 https://doi.org/10.56042/ijc.v62i3.71995 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(03) [Mar 2023]
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