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New quinazolinone-based Mannich bases: Synthesis and in vitro cytotoxic evaluation

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Field Value
 
Title New quinazolinone-based Mannich bases: Synthesis and in vitro cytotoxic evaluation
 
Creator Minh, Nguyen Van
Thao, Nguyen Thi Phuong
Linh, Nguyen Pham Duy
Vu, Tran Khac
 
Subject Cancer
Mannich
Cytotoxicity
Quinazolinone
 
Description 244-250
This research presents the synthesis of new quinazolinone-based Mannich bases in good yields via a three-step
procedure. The first step is the reaction of 6-hydroxyanthranilic acid 1 with an excess of acetic anhydride at 150°C for 2 h to
afford benzoxazinone 2 in 87% yield. Compound 2 is then reacted with 4-aminophenol in DMSO at reflux for 7 h to give
compound 3 in 75% yield. Finally, the reaction of 3 with paraformadehyde and secondary amines in ethanol affords new
quinazolinone-based Mannich bases 4a-c and 5a-e in 55-70% yields. The structure of Mannich bases have been
characterized by NMR and MS spectra. The bio-assay results show that some new Mannich bases exhibited weak to
moderate cytotoxic activity against SKLu-1 and MCF-7 cell lines.
 
Date 2023-03-17T07:19:19Z
2023-03-17T07:19:19Z
2023-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61536
https://doi.org/10.56042/ijc.v62i3.71995
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(03) [Mar 2023]