Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds
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Title |
Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds
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Creator |
Joshi, Kaushik
Mahida, Anil Rathod, Jayant |
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Subject |
Isoxazole
1,3,4-oxadiazole Biheterocycles Anti-fungal Anti-bacterial |
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Description |
237-243
Herein we have disclosed the design, synthesis, and study of the biological property of isoxazole and 1,3,4-oxadiazole containing framework. Set of 2-(4-(4-nitrophenoxy)phenyl)-5-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)phenyl)-1,3,4- oxadiazole derivatives have been constructed. Synthesized compounds have been screened for anti-fungal and anti-bacterial activities. Among them, Compound 8a have shown excellent anti-fungal activity against C.albicans fungi. Compound 8b and 8c have exhibited significant anti-bacterial activity with MIC 50 μg/mL against S. pyogenus and S. aureus pathogens, respectively. |
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Date |
2023-03-17T07:22:32Z
2023-03-17T07:22:32Z 2023-03 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61538 https://doi.org/10.56042/ijc.v62i3.72063 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(03) [Mar 2023]
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