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Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds

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Field Value
 
Title Synthesis and characterization of bioactive isoxazole and 1,3,4-oxadiazole heterocycle containing scaffolds
 
Creator Joshi, Kaushik
Mahida, Anil
Rathod, Jayant
 
Subject Isoxazole
1,3,4-oxadiazole
Biheterocycles
Anti-fungal
Anti-bacterial
 
Description 237-243
Herein we have disclosed the design, synthesis, and study of the biological property of isoxazole and 1,3,4-oxadiazole
containing framework. Set of 2-(4-(4-nitrophenoxy)phenyl)-5-(4-(5-(4-(pentyloxy)phenyl)isoxazol-3-yl)phenyl)-1,3,4-
oxadiazole derivatives have been constructed. Synthesized compounds have been screened for anti-fungal and anti-bacterial
activities. Among them, Compound 8a have shown excellent anti-fungal activity against C.albicans fungi. Compound 8b and 8c
have exhibited significant anti-bacterial activity with MIC 50 μg/mL against S. pyogenus and S. aureus pathogens, respectively.
 
Date 2023-03-17T07:22:32Z
2023-03-17T07:22:32Z
2023-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61538
https://doi.org/10.56042/ijc.v62i3.72063
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(03) [Mar 2023]