Chemical studies of chromanone-thiadiazole, pyridazine and thiosulfin hybrid
NOPR - NISCAIR Online Periodicals Repository
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Title |
Chemical studies of chromanone-thiadiazole, pyridazine and thiosulfin hybrid
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Creator |
Hegab, Mohamed I
Tolan, Hala E M Gad, Farouk A Abdel-Megeid, Farouk M E |
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Subject |
Chromanone
1,3,4-thiadiazole Piprazine 1,3,4-Oxadithiin 1,3,4,5,6-Oxatetrathiapin 1,2,4-Trithiolane 1,2,4,5-Tetrathiin |
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Description |
230-236
3-Chlorochromanon derivatives 4a,b are reacted with hydrazine hydrate to afford 3-hydrazino-2-tetrahydro(pyran or thiopyran)chroman-4-ones 5a,b. Then compound 5a,b is reacted with carbon disulfide and acetylacetone to give 5'-thiolo - 2-tetrahydro(pyrane or thiopyran)- spiro[chroman-3,2'- [1,3,4]-thiadiazole]-4-one 6a,b and 3', 5'-dimethyl- 2- tetrahydro(pyran or thiopyran) spiro [chroman-3,2'- piprazine]-4-one 7a,b, respectively. α-Chlorosulfenyl chlorides 2a,b are treated with thioacetic acid to form α-chloroalkyl disulfides 8a,b, the latter compounds 8a,b were treated with morpholine to furnish a mixture of 1,3,4-oxadithiins 9a,b, 1,3,4,5,6-oxatetrathiocins 10a,b, 1,2,4-trithiolanes 11a,b (cis- and trans-), 1,2,4,5-tetrathiins (cis- and trans-) 12a,b. The formation of the new compounds are confirmed by spectral (IR, 1H NMR, and MS) analysis. |
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Date |
2023-03-17T07:25:26Z
2023-03-17T07:25:26Z 2023-03 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61539 https://doi.org/10.56042/ijc.v62i3.72064 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(03) [Mar 2023]
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