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Chemical studies of chromanone-thiadiazole, pyridazine and thiosulfin hybrid

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Title Chemical studies of chromanone-thiadiazole, pyridazine and thiosulfin hybrid
 
Creator Hegab, Mohamed I
Tolan, Hala E M
Gad, Farouk A
Abdel-Megeid, Farouk M E
 
Subject Chromanone
1,3,4-thiadiazole
Piprazine
1,3,4-Oxadithiin
1,3,4,5,6-Oxatetrathiapin
1,2,4-Trithiolane
1,2,4,5-Tetrathiin
 
Description 230-236
3-Chlorochromanon derivatives 4a,b are reacted with hydrazine hydrate to afford 3-hydrazino-2-tetrahydro(pyran or
thiopyran)chroman-4-ones 5a,b. Then compound 5a,b is reacted with carbon disulfide and acetylacetone to give 5'-thiolo -
2-tetrahydro(pyrane or thiopyran)- spiro[chroman-3,2'- [1,3,4]-thiadiazole]-4-one 6a,b and 3', 5'-dimethyl- 2-
tetrahydro(pyran or thiopyran) spiro [chroman-3,2'- piprazine]-4-one 7a,b, respectively. α-Chlorosulfenyl chlorides 2a,b are
treated with thioacetic acid to form α-chloroalkyl disulfides 8a,b, the latter compounds 8a,b were treated with morpholine to
furnish a mixture of 1,3,4-oxadithiins 9a,b, 1,3,4,5,6-oxatetrathiocins 10a,b, 1,2,4-trithiolanes 11a,b (cis- and trans-),
1,2,4,5-tetrathiins (cis- and trans-) 12a,b. The formation of the new compounds are confirmed by spectral (IR, 1H NMR, and
MS) analysis.
 
Date 2023-03-17T07:25:26Z
2023-03-17T07:25:26Z
2023-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61539
https://doi.org/10.56042/ijc.v62i3.72064
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(03) [Mar 2023]