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Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity

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Title Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity
 
Creator Dhadda, Surbhi
Goswami, Prakash G
Yadav, Kalpana
Guleria, Anjali
Jangid, Dinesh K
Khandelwal, Chandra L
 
Subject Multicomponent reaction
C2-Functionalization
Pyridine-1-oxide
Ionic liquid
Green economic route
Antibacterial activity
 
Description 185-195
An innovative green economic route has been developed for one pot multicomponent synthesis of 5-methylpyridinium
derivatives by the reaction of 3-methylpyridine-1-oxide, aromatic aldehyde and β-ketoester catalysed by different ionic
liquids (ILs), [BMIM][OH], [BMIM][Cl], [BMIM][Ac] in good to excellent yields. A relative study reinforced that
[BMIM][OH] is the best IL for this C2-functionsalization reaction. The main highlights of this synthetic protocol are simple
work-up, cost effectiveness and environmentally benign processing. The synthesized derivatives have been assessed for
possible antibacterial activity against Staphylococcus aureus and Escherichia coli by using the microdilution method. The
results of antibacterial activity suggests that compound 4I shows best antibacterial activity and other compounds show good
to moderate activity.
 
Date 2023-03-17T07:38:22Z
2023-03-17T07:38:22Z
2023-03
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61547
https://doi.org/10.56042/ijc.v62i3.71997
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJC Vol.62(03) [Mar 2023]