Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity
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Title |
Green synthesis of 5-methylpyridinium derivatives by C2-functionalization of pyridine-1-oxide derivatives and their antibacterial activity
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Creator |
Dhadda, Surbhi
Goswami, Prakash G Yadav, Kalpana Guleria, Anjali Jangid, Dinesh K Khandelwal, Chandra L |
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Subject |
Multicomponent reaction
C2-Functionalization Pyridine-1-oxide Ionic liquid Green economic route Antibacterial activity |
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Description |
185-195
An innovative green economic route has been developed for one pot multicomponent synthesis of 5-methylpyridinium derivatives by the reaction of 3-methylpyridine-1-oxide, aromatic aldehyde and β-ketoester catalysed by different ionic liquids (ILs), [BMIM][OH], [BMIM][Cl], [BMIM][Ac] in good to excellent yields. A relative study reinforced that [BMIM][OH] is the best IL for this C2-functionsalization reaction. The main highlights of this synthetic protocol are simple work-up, cost effectiveness and environmentally benign processing. The synthesized derivatives have been assessed for possible antibacterial activity against Staphylococcus aureus and Escherichia coli by using the microdilution method. The results of antibacterial activity suggests that compound 4I shows best antibacterial activity and other compounds show good to moderate activity. |
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Date |
2023-03-17T07:38:22Z
2023-03-17T07:38:22Z 2023-03 |
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Type |
Article
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Identifier |
2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61547 https://doi.org/10.56042/ijc.v62i3.71997 |
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Language |
en
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Publisher |
NIScPR-CSIR,India
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Source |
IJC Vol.62(03) [Mar 2023]
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