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QbD-based optimization of guar gum suspension medium for optimum pourability and sedimentation volume

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Title QbD-based optimization of guar gum suspension medium for optimum pourability and sedimentation volume
 
Creator Sharma, Vaibhav
Monika, D
Nagpal, Kalpana
 
Subject Central Composite Design
Guar gum
Pharmaceutical suspensions
Optimization
QTPP
 
Description 223-230
A stable, adequately pourable guar-gum suspension medium has been developed by using the QbD approach. For this,
the QTPP is defined followed by its subset CMA (guar gum and sucrose concentration). The CQA are viscosity and
sedimentation volume. The target range for viscosity is 99 - 101.3 cps and sedimentation volume 0.98-1 for preparing the
optimized suspension. To achieve this optimization, the central composite design has been opted which would fit well to the
quadratic model. The quadratic equations and the ANOVA results are validated. The analysis phase of graphical and
numerical optimization suggested that 0.1g of guar-gum and 20g of sucrose can achieve an optimized viscosity and
sedimentation volume suspension. This contour plots and surface plots are utilized to check the combined interaction of the
variables. The checkpoint analysis reveal appropriate percentage variance, which signify the predictive ability of the
developed model and validated the design for an optimum suspension. Further, scale-up and stability studies will verify the
projected promising results which may be scaled up for its applications in pharmaceutical, food and chemical industries.
 
Date 2023-03-17T09:55:57Z
2023-03-17T09:55:57Z
2023-03
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/61555
https://doi.org/10.56042/ijct.v30i2.64967
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJCT Vol.30(2) [March 2023]