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Association of disease activity score (DAS) 28 with subsets of rheumatoid factor and anti-cyclic citrullinated peptides (anti-CCP) among rheumatoid arthritis patients in North India

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Title Association of disease activity score (DAS) 28 with subsets of rheumatoid factor and anti-cyclic citrullinated peptides (anti-CCP) among rheumatoid arthritis patients in North India
 
Creator Agarwal, Nishtha
Kapoor, Sanjeev
Garg, Shri Ram
Dubey, Shweta
AN, Malaviya
Nagpal, Puja Sawhney
 
Subject Autoantibody
Electrochemiluminescence
Immunological markers
Immunoturbidimetric assay
Sensitivity
Specificity
 
Description 297-302
Rheumatoid factor (RF), anticyclic citrullinated peptides (Anti-CCP), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) are used as disease markers for rheumatoid arthritis (RA). However, correlation of disease activity score (DAS) 28 with autoantibodies and inflammatory markers has not been studied in detail. Here, we have made an attempt to determine the association of DAS-28 with autoantibodies and inflammatory markers among the North Indian population. Further, we investigated the potential of subsets of autoantibodies in RA diagnosis. Disease activity was calculated by DAS-28-ESR calculator and levels of disease markers were estimated in serum. We noticed positive correlation between DAS-28, CRP (r=0.63, p=0.00) and ESR (r=0.72, p=0.00). Moderate and weak correlation was found with RF (r=0.41, p=0.00) and anti-CCP (r=0.25, p=0.011), respectively. Patients with positive subsets of both autoantibodies (RF+/Anti-CCP+) have shown a positive correlation with DAS-28. In our study, we found that the presence of RF and Anti-CCP in patient sera can increase the early detection rate of disease. But, for the diagnosis of disease in seronegative patients, more studies on biomarkers are required.
 
Date 2023-04-03T09:23:15Z
2023-04-03T09:23:15Z
2023-04
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61641
https://doi.org/10.56042/ijeb.v61i04.175
 
Language en
 
Source IJEB Vol.61(04) [Apr 2023]