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Essential role of Rnd1 in innate immunity during viral and bacterial infections

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Title Essential role of Rnd1 in innate immunity during viral and bacterial infections
Not Available
 
Creator Kumar, A.
Mishra, S.
Kumar, A.
Raut, A. A.
Sato, S.
Takaoka, A.
Kumar, H.
 
Subject Rnd1
 
Description Not Available
Intracellular and cell surface pattern-recognition receptors (PRRs) are an essential part of innate immune recognition and host defense. Here, we have compared the innate immune responses between humans and bats to identify a novel membrane-associated protein, Rnd1, which defends against viral and bacterial infection in an interferon-independent manner. Rnd1 belongs to the Rho GTPase family, but unlike other small GTPase members, it is constitutively active. We show that Rnd1 is induced by pro-inflammatory cytokines during viral and bacterial infections and provides protection against these pathogens through two distinct mechanisms. Rnd1 counteracts intracellular calcium fluctuations by inhibiting RhoA activation, thereby inhibiting virus internalisation. On the other hand, Rnd1 also facilitates pro-inflammatory cytokines IL-6 and TNF-α through Plxnb1, which are highly effective against intracellular bacterial infections. These data provide a novel Rnd1-mediated innate defense against viral and bacterial infections.
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Date 2023-04-03T10:57:49Z
2023-04-03T10:57:49Z
2022-06-02
 
Type Journal
 
Identifier Kumar, A., Mishra, S., Kumar, A., Raut, A. A., Sato, S., Takaoka, A., & Kumar, H. (2022). Essential role of Rnd1 in innate immunity during viral and bacterial infections. Cell death & disease, 13(6), 520.
2041-4889
http://krishi.icar.gov.in/jspui/handle/123456789/76653
 
Language English
 
Relation Not Available;
 
Publisher Nature Pub. Group