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Occurrence and characterization of genetic determinants of β-lactam-resistance in Escherichia coli clinical isolates

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Title Occurrence and characterization of genetic determinants of β-lactam-resistance in Escherichia coli clinical isolates
Not Available
 
Creator Tewari R
Ganaie F
Venugopal N
Mitra S
Shome R
Shome BR
 
Subject Antimicrobial resistance genes
Escherichia coli
Humans
Mobile genetic elements
β-Lactam resistance
 
Description Not Available
β-lactamase mediated resistance in Escherichia coli is a significant problem that requires immediate attention. Herein, we aim to characterize and understand the dynamics of the genetic determinants of β-lactam resistance (i.e. ESBL, AmpC, and MBL) in E. coli. Out of 203 E. coli isolates, genetic determinants of β-lactam resistance were identified in 50% (n = 101) of isolates. ESBL, AmpC, and MBL resistance determinants were detected in 78%, 40%, and 18% of isolates, respectively with blaCTX-M group 4 (48%), blaCMY (40%), and blaSIM (33%) as the most prevalent β-lactam resistance genes. Among these isolates, 45% harbored plasmid replicon types, with L/M (40%) and Y (33%) as the most dominant replicon types. Integrons were detected in 40% of such isolates, with Class-1 and Class-3 representing 62% and 55%, respectively. Overall, we observed high rate of genetic determinants of β-lactam-resistance in E. coli isolates recovered from patients in clinical settings. The co-occurrence of antimicrobial resistance genes and mobile genetic elements in a high percentage of isolates is a major concern and relates to complex resistance mechanisms. To combat the serious threat of antimicrobial resistance, it is imperative to develop strategies for robust surveillance and understand the molecular basis of resistance acquisition and transmission.
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Date 2023-04-10T06:41:16Z
2023-04-10T06:41:16Z
2022-02-24
 
Type Research Paper
 
Identifier Tewari R, Ganaie F, Venugopal N, Mitra S, Shome R, Shome BR. Occurrence and characterization of genetic determinants of β-lactam-resistance in Escherichia coli clinical isolates. Infect Genet Evol. 2022 Jun;100:105257. doi: 10.1016/j.meegid.2022.105257. Epub 2022 Feb 24. PMID: 35219866.
1567-1348
http://krishi.icar.gov.in/jspui/handle/123456789/76778
 
Language English
 
Relation Not Available;
 
Publisher Elsevier