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<p>Anti-Diabetic and Anti-oxidant Activities of <em>Devdarvadyarishta</em> in StreptozotocinInduced Diabetic Rats</p>

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Title Statement <p>Anti-Diabetic and Anti-oxidant Activities of <em>Devdarvadyarishta</em> in StreptozotocinInduced Diabetic Rats</p>
 
Added Entry - Uncontrolled Name Goyal, Chinky ; Shri Dhanwantry Ayurvedic College And Hospital Chandigarh
Sharma, Khemchand ; Rishikul Campus, Haridwar Uttarakhand Ayurved University
Joshi, Namrata ; Faculty of Ayurvedic Sciences, IMS, Banaras Hindu University
 
Uncontrolled Index Term Anti-oxidant, Devdarvadyarishta, Diabetes, Hypoglycaemic, Streptozotocin, Toxicity
 
Summary, etc. <p><em>Devdarvadyarishta</em> is a honey based medicated alcoholic formulation that has been documented to elicit hypoglycemic activity in Ayurvedic lexicon. The aim of this present study was to evaluate the anti-diabetic and anti-oxidant effect of <em>Devdarvadyarishta </em>in STZ induced Type II diabetic rats. 24 Wistar albino rats were distributed into four groups with six animals in each group <em>viz</em>., Group I (Normal Control Group), Group II (Diabetic control group), group III (Standard drug Glibenclamide at 10 mg/kg of body weight), group IV (<em>Devdarvadyarishta </em>at 2000 mg/kg of body weight). Diabetes was induced by intraperitoneal injection of STZ at dose level of 35 mg/kg. The whole study was conducted for 30 days. Changes in parameters like body weight, blood glucose, blood urea, serum cholesterol, triglycerides, creatinine, insulin, alkaline phosphatase, oral glucose tolerance test and liver anti-oxidant parameters <em>viz.</em>, superoxide dismutase and reduced glutathione were recorded. Histopathology of liver and pancreas was also done. Result showed significant improvement in parameters like body weight, lipid profile, blood glucose, serum creatinine, insulin and alkaline phosphatase which were almost analogous to potent antidiabetic drug glibenclamide. Histopathological studies reinforce the healing of pancreas by increase in pancreatic islet numbers and size, amelioration in atrophy, well-rejuvenated normal cellular arrangement and reduced necrosis with normal blood vessels in liver by test drug as a possible mechanism of its antidiabetic and anti-oxidant activity our study suggests that <em>Devdarvadyarishta</em> suppresses the symptoms of diabetes and diabetes related oxidative stress in animal study.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-04-11 16:28:28
 
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http://op.niscair.res.in/index.php/IJTK/article/view/33710
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 1 (2023): Indian Journal of Traditional Knowledge
 
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