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<p>Hepatoprotective activity of <em>Mitragyna speciosa</em> Korth. on Liver Damage Caused by <em>Tuak</em></p><p> </p>

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Title Statement <p>Hepatoprotective activity of <em>Mitragyna speciosa</em> Korth. on Liver Damage Caused by <em>Tuak</em></p><p> </p>
 
Added Entry - Uncontrolled Name Panjaitan, Ruqiah Ganda Putri; Departement of Biology Education, Faculty of Teacher Training and Education, Tanjungpura University, Pontianak, Indonesia
Mery, Monalisa Wendy; Departement of Biology Education, Faculty of Teacher Training and Education, Tanjungpura University, Pontianak, Indonesia
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Uncontrolled Index Term Kratom leaves, Liver histopathological, Serum enzymes, Tuak
 
Summary, etc. <p>This study aims to evaluate the protection and restoration capacity of <em>kratom</em> leaves extracts on liver damage caused by <em>tuak</em>. Group A consist of 12 mice and divided into A1 administered 0.5 mL/20 g body weight aquadest, A2 administered <em>kratom</em> leaves ethanol extract at dose 0.29 mg/20 g body weight and A3 administered silymarin at dose 0.70 mg/20 g body weight on days 1 to 7, then continued given <em>tuak</em> at dose 0.26 mL/20 g body weight on days 8 to 14. Group B consist of <br /> 12 mice and divided into B1, B2, and B3, on days 1 to 7 they were administered <em>tuak</em> at dose 0.26 mL/20 g body weight then continued with aquadest at dose 0.5 mL/20 g body weight (B1), <em>kratom</em> leaves ethanol extract at dose 0.29 mg/20 g body weight (B2), and silymarin at dose 0.70 mg/20 g body weight on days 8 to 14 (B3). The average levels of ALT enzyme in the treatment groups respectively showed 29.13±0.40 U/L (A1); 25.25±0.69 U/L (A2); 20.51±1.00 U/L (A3) and 31.20±0.47 U/L (B1); 26.95±0.62 U/L (B2); 23.31±0.89 (B3) (p&lt;0.05). Whereas, the average levels of AST respectively at 34.23±0.63 U/L (A1); 28.64±0.40 U/L (A2); 25.13±0.83 U/L (A3) and 35.69±0.63 U/L (B1); 30,83±0.63 (B2); 27.31±0.83 (B3) (p&lt;0.05). The average scoring for the treatment groups resulted in 2.67; 2.33; 1.33 respectively A1, A2, and <br /> A3 (p&lt;0.01) and 2.00; 0.67; 0.33 respectively B1, B2 and B3 (p&lt;0.01). It is concluded that <em>kratom</em> leaves are not effective <br /> to protect and to restore the liver.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-04-11 16:28:28
 
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http://op.niscair.res.in/index.php/IJTK/article/view/46266
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 1 (2023): Indian Journal of Traditional Knowledge
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/46266/465548546