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<p>Assessment of dermal toxicity of mustard oil based formulation of <em>Nerium indicum</em> Mill.</p><p> </p>

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Title Statement <p>Assessment of dermal toxicity of mustard oil based formulation of <em>Nerium indicum</em> Mill.</p><p> </p>
 
Added Entry - Uncontrolled Name Patel, Vivek Kumar; Institute of Post Graduate Teaching and Research in Ayurveda.
Acharya, Rabinarayan ; Institute of Post Graduate Teaching and Research in Ayurveda.
Nariya, Mukesh ; Institute of Post Graduate Teaching and Research in Ayurveda.
 
Uncontrolled Index Term Acute dermal toxicity, Karavira, Nerium indicum, Rakta Karavira Taila, Sub-acute dermal toxicity
 
Summary, etc. <p><em>Nerium indicum </em>Mill. with red flowers belong to family <em>Apocynaceae </em>is considered as botanical source of <em>Rakta Karavir</em>a drug of <em>Upavisha</em> (semi-poisonous) category of Ayurvedic Pharmacopeia of India. Till date <em>Rakta Karavira Taila </em>(mustard oil based formulation of root bark of <em>Rakta Karavira</em>) has not been evaluated pharmacologically. In present study, acute and repeated dose 28 day dermal toxicity studies of <em>Rakta Karavira Taila </em>was carried out in Charles foster albino rats. Acute dermal toxicity study was assessed at a single dermal application of drug at limit dose of 2000 mg/kg body weight of rats and observed for fourteen consecutive days. The repeated dose 28-day dermal toxicity study was assessed on repeated dermal applications at limit dose of 1000 mg/kg body weight of rats for 28 days consecutive days as per OECD guideline. The test medication was applied equally over a region covering rats body surface area of about 10%. Effects on body weight, haematological, ponderal changes, biochemical, and histological studies were used to evaluate the toxicity of the <em>Rakta Karavira Taila</em>. No mortality and toxicity were observed on single dermal application at limit dose level of 2000 mg/kg in acute dermal toxicity study. On repeated dermal applications of <em>Rakta Karavira Taila </em>at limit dose of 1000 mg/kg, showed statistically significant decrease in weight of testes, increase in WBC and platelet count while rest of hematological and biochemical parameters are not affected in comparison to control group. Histopathological study showed inflammation and fatty degenerative changes in liver and kidney, degenerative changes in seminiferous tubules and decrease in spermatogenesis in drug administered group. Medicated oil prepared out of root bark of <em>Nerium indicum</em> with red flower with mustard oil has potential to produce adverse effect particularly on male reproductive system therefore, should not be used for longer duration at higher dose level.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2023-04-11 16:28:28
 
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http://op.niscair.res.in/index.php/IJTK/article/view/33677
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 22, ##issue.no## 1 (2023): Indian Journal of Traditional Knowledge
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJTK/article/download/33677/465504030
http://op.niscair.res.in/index.php/IJTK/article/download/33677/465504033
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http://op.niscair.res.in/index.php/IJTK/article/download/33677/465504035
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http://op.niscair.res.in/index.php/IJTK/article/download/33677/465504037
http://op.niscair.res.in/index.php/IJTK/article/download/33677/465504038