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Allosteric modulation on specific gene mutated Vitamin D receptor by essential PUFAs and its distinct molecular effects on type 2 diabetes mellitus

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Title Allosteric modulation on specific gene mutated Vitamin D receptor by essential PUFAs and its distinct molecular effects on type 2 diabetes mellitus
 
Creator Hari, Balaji
TN, Shilpa
S, Jubie
B, Duraiswamy
 
Subject Arachidonic Acid
Docosahexaenoic Acid
Eicosapentaenoic Acid
Polyunsaturated fatty acids
Type-2 Diabetes Mellitus
Vitamin D Receptor
Vitamin D
3T3-L1
 
Description 339-351
A serious health threat affecting the T2DM group is evident more cases T2DM are diagnosed. In this research, we choose to
research into all of this possible mechanism of 3T3-L1 Cell lines and Molecular Docking studies Schrodinger software identified
Vitamin D, Omega-3, and 6 PUFAs (EPA DHA & AA) Compounds of hydrophilic and hydrophobic pocket throughout molecular
modeling besides T2DM. A group of three analog VDRs is being developed for discovery treatment with T2DM. Its use as it was
agreed to run a molecular cell culture and docking study. Recognize the binding method involving the compound in T2DM through
ADME prediction. The molecular dynamics simulation was enhanced by confirmation of the strength of the possible composite
binding. Based on the computational results, the Omega-3 and 6 PUFAs compound encourages energy interaction. The composite
contains an in vitro anti-diabetic activity; the compounds have clearly shown that they are active on T2DM. Our studies provide
vital information on the findings of the bimolecular T2DM inhibitors.
 
Date 2023-04-12T11:34:32Z
2023-04-12T11:34:32Z
2023-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61725
https://doi.org/10.56042/ijbb.v60i4.58785
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(04) [April 2023]