Record Details

Antioxidant mediated defensive potency of Caesalpinia bonducella nut on Acetaminophen-inebriated spleen and cardiotoxicity: Implications on oxidative stress and tissue morphology in an In vivo model

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Antioxidant mediated defensive potency of Caesalpinia bonducella nut on Acetaminophen-inebriated spleen and cardiotoxicity: Implications on oxidative stress and tissue morphology in an In vivo model
 
Creator Nithiyanandam, Sangeetha
Jaisankar, Vaishnavi
Parthasarathy, Manisha
Katturajan, Ramkumar
Evan Prince, Sabina
 
Subject Antioxidants
APAP
Bonduc nut
Cardiotoxicity
Free radical scavenging
Spleen injury
 
Description 297-306
Overdosing on medications can be unintentional or deliberate. Acetaminophen (APAP) is a widely used over-the-counter
analgesic and antipyretic drug. APAP overdose can induce spleen and cardiotoxicity apart from hepatotoxicity. Bonduc nut
is well-known for its medicinal and therapeutic properties. More scientific data is necessary to be therapeutically relevant.
This study examined the effects of Bonduc nut extract (BNE) on APAP-induced spleen and cardiotoxicity in Wistar albino
rats. The rats were divided into five groups of six rats each. In vitro assays were carried out to analyze antioxidant activity
and free radical scavenging activity in aqueous, ethanol, and methanol solvents in Bonduc nut powder. Total phenolic
content, DPPH, catalase, and peroxidase activity were used to test antioxidant activity. The rats were euthanized after the
study period to examine antioxidant parameters such as superoxide dismutase, catalase, reduced glutathione, and glutathione
peroxidase, as well as lipid peroxidation and histopathology of the spleen and heart tissues. Results suggest that compared to
other solvents aqueous has better Invitro antioxidant ability and the same extract significantly increased the antioxidant and
reduced lipid peroxidation followed by restoring the tissue morphology in APAP-induced spleen and cardiotoxicity. The
outcome of the study revealed that aqueous BNE has a significant protective efficacy against APAP-induced spleen and
cardiotoxicity in Wistar albino rats
 
Date 2023-04-12T11:50:19Z
2023-04-12T11:50:19Z
2023-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61729
https://doi.org/10.56042/ijbb.v60i4.72352
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(04) [April 2023]