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Computer-Aided vaccine design for selected positive-sense single stranded RNA viruses

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Title Computer-Aided vaccine design for selected positive-sense single stranded RNA viruses
 
Creator Jeyaraj Pandian, Chitra
Murugan, N Arul
Rajendren, SM
 
Subject Epitope prediction
Immunoinformatics
Hepatitis C virus
Dengue virus
Coronaviruses
Chikungunya virus
 
Description 281-296
Spontaneous mutations and lack of replication fidelity in positive-sense single stranded RNA viruses (+ssRNA virus) result
in emergence of genetic variants with diverse viral morphogenesis and surface proteins that affect its antigenicity. This high
mutability in +ssRNA viruses has induced antiviral drug resistance and ability to overcome vaccines that subsequently resulted
in rapid viral evolution and high mortality rate in human and livestock. Computer aided vaccine design and immunoinformatics
play a crucial role in expediting the vaccine production protocols, antibody production and identifying suitable immunogenic
regions or epitopes from the genome sequences of the pathogens. T cell and B cell epitopes can be identified in pathogens by
immunoinformatics algorithms and methods that enhance the analysis of protective immunity, vaccine safety, immunity
modelling and vaccine efficacy. This rapid and cost-effective computational vaccine design promotes development of potential
vaccine that could induce immune response in host against rapidly mutating pathogens like +ssRNA viruses. Epitope-based
vaccine is a striking concept that has been widely employed in recent years to construct vaccines targeting rapidly mutating
+ssRNA viruses. Therefore, the present review provides an overview about the current progress and methodology in computeraided
vaccine design for the most notable +ssRNA viruses namely Hepatitis C virus, Dengue virus, Chikungunya virus and
Coronaviruses. This review also highlights the applications of various immunoinformatics tools for vaccine design and for
modelling immune response against +ssRNA viruses.
 
Date 2023-04-12T11:53:48Z
2023-04-12T11:53:48Z
2023-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61730
https://doi.org/10.56042/ijbb.v60i4.68236
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(04) [April 2023]