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Current trends and advances of Quorum sensing inhibitors and their biotechnological applications

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Title Current trends and advances of Quorum sensing inhibitors and their biotechnological applications
 
Creator Shamshad, Samer
Rajagopal, Senthilkumar
 
Subject Applications
Cell communication
Pathogen
QS inhibitors
QS
 
Description 255-280
Serious setbacks were witnessed in shrimp farming, the food industry, and the ship industry during the past three
decades primarily due to bacterial pathogens that coordinate by quorum sensing (QS). The influence of bacterial pathogens
utilizing QS. The impact of QS cell communication on public health is extremely disastrous in terms of spread, spectrum,
apart from their economic impact. The overuse of antibiotics has increased drastically to battle bacterial infections, including
tons of antibiotics are distributed in the biosphere. Due to the indiscriminate use of antibiotics, multiple antibiotic-resistant
strains have emerged, as the antibiotic resistance genes are being transferred to bacteria of terrestrial animals, humans, and
pathogens. The increased public awareness of the negative drawbacks caused by over-exposure to antibiotics, also the
emergence of multiple antibiotic resistant pathogenic stains led to the search for alternatives and unique solutions. One such
unconventional, promising method is the interruption of bacterial cell to cell communication, which is currently termed QS
inhibition. Now-a-days, QS inhibition is the potential objective for antimicrobial chemotherapy. This review summarizes the
regulatory factors that attenuate the QS activities of deadly pathogens and discusses their distinctive characteristics.
Improving awareness of the natural roles of regulatory elements might be useful in unveiling inhibitor applications to
understand how QS is inhibited in pathogenic bacteria by different QS inhibitors.
 
Date 2023-04-12T11:56:12Z
2023-04-12T11:56:12Z
2023-04
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscpr.res.in/handle/123456789/61731
https://doi.org/10.56042/ijbb.v60i4.65104
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source IJBB Vol.60(04) [April 2023]