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Antimicrobial, antioxidant and anti-inflammatory activities of seeds from emblica officinalis (Gaertn.)

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Title Antimicrobial, antioxidant and anti-inflammatory activities of seeds from emblica officinalis (Gaertn.)
Not Available
 
Creator Singh PG
Jain AS
Sridhara Setty PB
Sushma BV
Patil SS
Ashwini P
Gopenath TS
Suresh KP
Dugganaboyana GK
Murugesan K
Gnanasekaran A
Shivamallu C
Kollur SP
Srinivasa C
Raghavendra HL
Rudrapathy P
Basalingappa KM
 
Subject Emblica officinalis
antioxidant
lipoxygenase inhibition
antimicrobial
LC-MS analysis
 
Description Not Available
There is a shred of evidence to suggest that Emblica officinalis Gaertn, the botanical name for amla seeds, has greater medicinal potential than amla fruit. We conducted this work to assess the anti-inflammatory, antibacterial, and antioxidant capacities of E. officinalis seed extracts. The bioactive components from the seeds were fractionated using chloroform, hexane, methanol, and diethyl ether, according to the polarity of the solvents. The total amount of phenolic and flavonoid was estimated. Both the reducing power and antioxidant capacities of the extracts were evaluated using the DPPH (1,1-diphenyl-2-picryl-hydrazyl) technique. 15-lipoxygenase (LOX) was inhibited by seed extracts at doses ranging from 5 to 25 micrograms. In silico docking was employed to assess the results. Some human pathogenic microorganisms were tested for their antibacterial activity using the agar disc diffusion method. Escherichia coli, Proteus vulgaris, and Klebsiella pneumonia were inhibited by a methanolic extract with an IC50 value of 58g, making it the most common organic solvent extract. Methanolic extracts also showed good antioxidant and antibacterial activity. Our investigation led us to discover that amla seeds have anti-inflammatory, antioxidant, and antibacterial effects
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Date 2023-04-12T07:16:49Z
2023-04-12T07:16:49Z
2022-08-31
 
Type Research Paper
 
Identifier Singh et al. Bioinformation 18(8): 683-691 (2022)
0973-8894
http://krishi.icar.gov.in/jspui/handle/123456789/76804
 
Language English
 
Relation Not Available;
 
Publisher Biomedical Informatics