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“In vivo” free radical scavenging efficacy of beebread against biochemical alterations induced by Salmonella enterica serovar Typhimurium

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Title “In vivo” free radical scavenging efficacy of beebread against biochemical alterations induced by Salmonella enterica serovar Typhimurium
 
Creator Kaur, R
Kumar, N R
Harjai, K
 
Subject Antioxidant
Honey bee products
Multidrug resistance
Oxidative stress
Protective effect
Typhoid
 
Description 189-194
Salmonella typhimurium induced hepatic and renal toxicity was investigated using standard laboratory techniques in
mice. BALB/c mice were divided into ten groups (8 mice per group). Group (Gp) 1 served as normal, and were
administrated with normal saline orally, and Gp2 served as infected, and were injected bacteria (2×104 CFU/mL) only, while
Gp3, 5, 7 and, 9 were administrated beebread (250 mg/kg body weight) of Helianthus annus, Brassica campestris, Zea mays
and vitamin C respectively for 21 days without Salmonella infection, and Gp 4, 6, 8 and, 10 were administrated beebread
(250 mg/kg bw) of Helianthus annus, Brassica campestris, Zea mays and vitamin C respectively for 21 days with a bacterial
infection. Serum activities of hepatic and renal enzymes were analysed. A significant increase was observed in biochemical
enzymes in Salmonella infected group on the 5th day but after the administration of beebread of different crops, relief was
observed to be near normal. This alleviation was more with beebread of Helianthus annus. Furthermore, administration of
beebread without bacteria did not show any negative effects in mice. Thus, the results indicate that aqueous extract of
beebread of different crops is safe and can be exploited in healthcare delivery systems.
 
Date 2023-04-13T12:22:19Z
2023-04-13T12:22:19Z
2023-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/61739
https://doi.org/10.56042/ijtk.v22i1.47766
 
Language en
 
Relation A61K 35/64
A61K 35/644
A61K 36/00
A61K 36/28
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.22(1) [January 2023]