Record Details

Evaluation of gastroprotective effect of jujube honey in ethanol-induced stomach ulcer in mice

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Evaluation of gastroprotective effect of jujube honey in ethanol-induced stomach ulcer in mice
 
Creator Benmouloud, Abdelouafi
Zatra, Yamina
Belkadi, Asma
Halli, Latifa
Kacimi, Lilia
Souames, Samir
 
Subject Anti inflammatory
Antioxidant
Bioactive compounds
Gastroprotective
Jujube honey
Stomach ulcer
 
Description 150-159
Honey has been widely documented to have therapeutic benefits, especially on the healing of wounds, digestive disorders, and as an antimicrobial agent. It’s known that stomach ulcers are one of the most prevalent diseases that affect humans with no effective treatment. The objective of this study was to investigate the gastroprotective effects of jujube honey against ethanol-induced gastric ulcer in mice and to explore possible mechanism of its action on the gastric mucosa. Stomach’s tissues were examined for ulcerative lesions and white blood cell count (WBC), plasma C-reactive protein (CRP) and nitric oxide (NO) for clinical inflammation evaluation. The antioxidant enzyme activities were investigated using the measurement of superoxide dismutase (SOD) and catalase. Treatment with jujube honey reduced the ulcer index and preserved gastric tissue. It also decreased the inflammatory response by reducing WBC and plasma levels of CRP and NO in ulcerative group. In addition, jujube honey-treated group showed increased antioxidant enzyme activities of catalase and SOD. Furthermore, diluted jujube honey is more effective in preserving mucosal gastric integrity. In conclusion, these findings suggest that jujube honey, especially with dilution, may exert a protective effect against ethanol-induced gastric ulcer, through the improvement of antioxidant system and suppression of the inflammatory response via its bioactive compounds.
 
Date 2023-04-13T12:33:31Z
2023-04-13T12:33:31Z
2023-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/61743
https://doi.org/10.56042/ijtk.v22i1.33680
 
Language en
 
Relation A61K 31/70
A61K 35/644
A61K 36/00
A61P 29/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.22(1) [January 2023]