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Hepatoprotective activity of Mitragyna speciosa Korth. on liver damage

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Title Hepatoprotective activity of Mitragyna speciosa Korth. on liver damage
 
Creator Panjaitan, R G P
Mery, M W
 
Subject Kratom leaves
Liver histopathological
Serum enzymes
Tuak
 
Description 133-139
This study aims to evaluate the protection and restoration capacity of kratom leaves extracts on liver damage caused by
tuak. Group A consist of 12 mice and divided into A1 administered 0.5 mL/20 g body weight aquadest, A2 administered
kratom leaves ethanol extract at dose 0.29 mg/20 g body weight and A3 administered silymarin at dose 0.70 mg/20 g body
weight on days 1 to 7, then continued given tuak at dose 0.26 mL/20 g body weight on days 8 to 14. Group B consist of
12 mice and divided into B1, B2, and B3, on days 1 to 7 they were administered tuak at dose 0.26 mL/20 g body weight then
continued with aquadest at dose 0.5 mL/20 g body weight (B1), kratom leaves ethanol extract at dose 0.29 mg/20 g body
weight (B2), and silymarin at dose 0.70 mg/20 g body weight on days 8 to 14 (B3). The average levels of ALT enzyme in
the treatment groups respectively showed 29.13±0.40 U/L (A1); 25.25±0.69 U/L (A2); 20.51±1.00 U/L (A3) and
31.20±0.47 U/L (B1); 26.95±0.62 U/L (B2); 23.31±0.89 (B3) (p
 
Date 2023-04-13T12:37:14Z
2023-04-13T12:37:14Z
2023-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/61745
https://doi.org/10.56042/ijtk.v22i1.46266
 
Language en
 
Relation A61K 36/00
A61K 36/185
A61K 45/06
A61P 1/16
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.22(1) [January 2023]