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Pharmacodynamics, metabolomics and pathological studies on mechanisms of traditional benefits of Angelica sinensis in blood circulation

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Title Pharmacodynamics, metabolomics and pathological studies on mechanisms of traditional benefits of Angelica sinensis in blood circulation
 
Creator Yang, Xiujuan
Hai, Yunxiang
Yang, Zhijun
Wang, Pengqian
Li, Jiameng
Hao, Danli
Zhang, Miao
Deng, Yi
Sui, Feng
 
Subject Activating blood
Angelica sinensis
Metabolomics and pathological studies
Pharmacodynamics
Traditional benefits
 
Description 122-132
Angelica sinensis is a rich source of medically important active molecules that need in-depth understanding on its action
mechanisms. Therefore, through pharmacodynamics, metabolomics, and network pharmacology, the traditional benefits of
A. sinensis in blood circulation was studied using 24 randomly selected Sprague-Dawley (SD) rats. Measurement of the
blood rheological parameters for whole blood viscosity (WBV) and plasma viscosity (PV), and inspection of the heart and
lung tissues pathological changes were undertaken using molecular and bioinformatic techniques. Multivariate statistical
analysis and establishment of the model of the relationship between metabolite expression and sample categories to test the
prediction of sample categories were performed. Screening was undertaken to find the potential metabolites for A. sinensis
to treat blood stasis syndrome and find related metabolic pathways. Active ingredients of A. sinensis and targets and
building of an “effect component-target” network was undertaken, A. sinensis was confirmed to improve blood stasis
syndrome in rats and improve heart and lung pathology to varying degrees. Compared with the blood stasis model group, A.
sinensis significantly reduced WBV and PV in hemorheology (p
 
Date 2023-04-13T12:40:20Z
2023-04-13T12:40:20Z
2023-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/61746
https://doi.org/10.56042/ijtk.v22i1.53106
 
Language en
 
Relation A61K 36/00
A61K 36/23
A61K 45/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.22(1) [January 2023]