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Assessment of dermal toxicity of mustard oil based formulation of Nerium indicum Mill.

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Title Assessment of dermal toxicity of mustard oil based formulation of Nerium indicum Mill.
 
Creator Patel, Vivek Kumar
Acharya, Rabinarayan
Archana, Kumari
Nariya, Mukeshkumar
 
Subject Acute dermal toxicity
Karavira
Nerium indicum
Rakta Karavira Taila
Sub-acute dermal toxicity
 
Description 76-82
Nerium indicum Mill. with red flowers belong to family Apocynaceae is considered as botanical source of Rakta
Karavira drug of Upavisha (semi-poisonous) category of Ayurvedic Pharmacopeia of India. Till date Rakta Karavira Taila
(mustard oil based formulation of root bark of Rakta Karavira) has not been evaluated pharmacologically. In present study,
acute and repeated dose 28 day dermal toxicity studies of Rakta Karavira Taila was carried out in Charles foster albino rats.
Acute dermal toxicity study was assessed at a single dermal application of drug at limit dose of 2000 mg/kg body weight of
rats and observed for fourteen consecutive days. The repeated dose 28-day dermal toxicity study was assessed on repeated
dermal applications at limit dose of 1000 mg/kg body weight of rats for 28 days consecutive days as per OECD guideline.
The test medication was applied equally over a region covering rats body surface area of about 10%. Effects on body
weight, haematological, ponderal changes, biochemical, and histological studies were used to evaluate the toxicity
of the Rakta Karavira Taila. No mortality and toxicity were observed on single dermal application at limit dose level
of 2000 mg/kg in acute dermal toxicity study. On repeated dermal applications of Rakta Karavira Taila at limit dose of
1000 mg/kg, showed statistically significant decrease in weight of testes, increase in WBC and platelet count while rest of
hematological and biochemical parameters are not affected in comparison to control group. Histopathological study showed
inflammation and fatty degenerative changes in liver and kidney, degenerative changes in seminiferous tubules and decrease
in spermatogenesis in drug administered group. Medicated oil prepared out of root bark of Nerium indicum with red flower
with mustard oil has potential to produce adverse effect particularly on male reproductive system therefore, should not be
used for longer duration at higher dose level.
 
Date 2023-04-13T13:11:12Z
2023-04-13T13:11:12Z
2023-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/61752
https://doi.org/10.56042/ijtk.v22i1.33677
 
Language en
 
Relation A61K 9/06
A61K 36/00
A61K 45/06
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.22(1) [January 2023]