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Anti-diabetic and anti-oxidant activities of Devdarvadyarishta in streptozotocin induced diabetic rats

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Title Anti-diabetic and anti-oxidant activities of Devdarvadyarishta in streptozotocin induced diabetic rats
 
Creator Goyal, Chinky
Sharma, Khemchand
Joshi, Namrata
 
Subject Anti-oxidant
Devdarvadyarishta
Diabetes
Hypoglycaemic
Streptozotocin
Toxicity
 
Description 68-75
Devdarvadyarishta is a honey based medicated alcoholic formulation that has been documented to elicit hypoglycemic activity in Ayurvedic lexicon. The aim of this present study was to evaluate the anti-diabetic and anti-oxidant effect of Devdarvadyarishta in STZ induced type II diabetic rats. 24 Wistar albino rats were distributed into four groups with six animals in each group viz., Group I (Normal Control Group), Group II (Diabetic control group), group III (Standard drug Glibenclamide at 10 mg/kg of body weight), group IV (Devdarvadyarishta at 2000 mg/kg of body weight). Diabetes was induced by intraperitoneal injection of STZ at dose level of 35 mg/kg. The whole study was conducted for 30 days. Changes in parameters like body weight, blood glucose, blood urea, serum cholesterol, triglycerides, creatinine, insulin, alkaline phosphatase, oral glucose tolerance test and liver anti-oxidant parameters viz., superoxide dismutase and reduced glutathione were recorded. Histopathology of liver and pancreas was also done. Result showed significant improvement in parameters like body weight, lipid profile, blood glucose, serum creatinine, insulin and alkaline phosphatase which were almost analogous to potent antidiabetic drug glibenclamide. Histopathological studies reinforce the healing of pancreas by increase in pancreatic islet numbers and size, amelioration in atrophy, well-rejuvenated normal cellular arrangement and reduced necrosis with normal blood vessels in liver by test drug as a possible mechanism of its antidiabetic and anti-oxidant activity our study suggests that Devdarvadyarishta suppresses the symptoms of diabetes and diabetes related oxidative stress in animal study.
 
Date 2023-04-13T13:13:40Z
2023-04-13T13:13:40Z
2023-04
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscpr.res.in/handle/123456789/61753
https://doi.org/10.56042/ijtk.v22i1.33710
 
Language en
 
Relation A61K 9/00
A61K 35/644
A61K 36/00
 
Publisher NIScPR-CSIR, India
 
Source IJTK Vol.22(1) [January 2023]