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One pot synthesis of 1,3,4-oxadiazoles by Lewis acid catalyst and their study of 2D-QSAR, antimicrobial and anti-tubercular activities

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Title One pot synthesis of 1,3,4-oxadiazoles by Lewis acid catalyst and their study of 2D-QSAR, antimicrobial and anti-tubercular activities
 
Creator Patel, J A
Patel, N B
 
Subject 1,3,4-oxadiazole
2D-QSAR study
Antimicrobial activity
Antitubercular activity
Antimalarial activity
 
Description 355-364
In the present work, Lewis acid catalyzed reactions have been carried out between mefenamic acid, substituted aldehyde and
semicarbazide in the presence of ZnCl2 to give the final compounds (E)-N-(2-(5-((substitutedene)amino)-1,3,4-oxadiazol-2-
yl)phenyl)-2,3-dimethylaniline, A. The synthesized compounds have been characterized by IR, 1H NMR, 13C NMR, mass
spectral studies and biologically screened for the antimicrobial, antitubercular and antimalarial activities. Among the screened
molecules, the molecules A1, A3, A4, A6, A8, A9, A10 show activity against different antibacterial species. The compounds,
active against different antifugal species are A3, A7, A8, A9 against C. albicans, compound A3 is active against A. niger.
Whereas, compound A9 shows good antimycobacterial activity. Compound A6 having 4-hydroxybenzenesubstituent exhibits
promising activity against P. falciparum antimalerial parasite.
 
Date 2023-04-17T10:16:32Z
2023-04-17T10:16:32Z
2023-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61773
https://doi.org/10.56042/ijc.v62i4.442
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(04) [Apr 2023]