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Design, synthesis and antimicrobial evaluation of benzimidazole containing 4-thiazolidinone based 5-arylidene derivatives

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Title Design, synthesis and antimicrobial evaluation of benzimidazole containing 4-thiazolidinone based 5-arylidene derivatives
 
Creator N C, Desaia
Shah, K N
Dave, B P
 
Subject Benzimidazole
Thiazolidinone
Arylidene
Antibacterial activity
Antifungal activity
 
Description 318-326
In an attempt to design a potent class of antimicrobials, we have synthesized benzimidazole derivatives based on 4-thiazolidinone which possessed 5-arylidenes 5a-o by using different catalysts under multistep conventional synthesis.Structures of the synthesized compounds have been established based on spectral data and compounds have been screenedfor their antimicrobial activity. Compound 5j shows maximum potency against all Gram-positive bacteria with a minimuminhibitory concentration (MIC) in the range of 25-50 μg/mL while moderate activity against Gram-negative bacterial strainsis observed with a MIC value of 62.50 μg/mL. Compound 5n is found to be the most active against fungal strains with aMIC value of 250 μg/mL.
 
Date 2023-04-17T10:27:25Z
2023-04-17T10:27:25Z
2023-04
 
Type Article
 
Identifier 2583-1321 (Online); 0019-5103 (Print)
http://nopr.niscpr.res.in/handle/123456789/61778
https://doi.org/10.56042/ijc.v62i4.408
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJC Vol.62(04) [Apr 2023]