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High fat diet induces anti-inflammatory effect in experimental colitis

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Title High fat diet induces anti-inflammatory effect in experimental colitis
 
Creator Emlik, Huseyin
Bayiroglu, Fahri
Mis, Leyla
Kaya, Mehmet Salih
Gunbatar, Nizamettin
 
Subject Intermittent fasting
Inflammation
Inflammatory bowel disease (IBD)
Ulcerative colitis
 
Description 357-363
The prevalence of ulcerative colitis, one of the inflammatory bowel diseases, has been increasing worldwide. Though fatty
diet leads to development of colitis, only little is known about the separate and combined effects of different fat compositions
and intermittent fasting, and the effects of preventative dietary changes on experimental colitis. In this study, we investigated
the effect of feeding type and frequency on the inflammation ulcerative colitis. Five groups, each comprising 7 male Wistar
albino rats, were formed viz. Colitis (as a control), High sucrose diet + Colitis, High sucrose diet + Intermittent fasting + Colitis,
High fat diet + Colitis, High fat diet + Intermittent fasting + Colitis. The intermittent fasting group (experimental group) was not
fed for 2 days (non-consecutive) in a week (except water), otherwise fed with ad libitum. Following the 7-wk feeding
application, the rats were treated with intrarectal administration of 4% acetic acid (pH 2.4). After the rats were sacrificed, the
levels of interleukin-1β, insulin, C-reactive protein, leptin, tumor necrosis factor-α, interleukin-6, insulin-like growth factor-1
and adiponectin were analyzed from the blood samples. Analyzes of results revealed a statistically significant decrease in
interleukin-1β, C-reactive protein, tumor necrosis factor-α, interleukin-6 and adiponectin levels in High sucrose diet
+ Intermittent fasting + Colitis and High fat diet + Intermittent fasting + Colitis groups (P
 
Date 2023-05-01T07:05:29Z
2023-05-01T07:05:29Z
2023-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61826
https://doi.org/10.56042/ijeb.v61i05.853
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(05) [May 2023]