High fat diet induces anti-inflammatory effect in experimental colitis
NOPR - NISCAIR Online Periodicals Repository
View Archive InfoField | Value | |
Title |
High fat diet induces anti-inflammatory effect in experimental colitis
|
|
Creator |
Emlik, Huseyin
Bayiroglu, Fahri Mis, Leyla Kaya, Mehmet Salih Gunbatar, Nizamettin |
|
Subject |
Intermittent fasting
Inflammation Inflammatory bowel disease (IBD) Ulcerative colitis |
|
Description |
357-363
The prevalence of ulcerative colitis, one of the inflammatory bowel diseases, has been increasing worldwide. Though fatty diet leads to development of colitis, only little is known about the separate and combined effects of different fat compositions and intermittent fasting, and the effects of preventative dietary changes on experimental colitis. In this study, we investigated the effect of feeding type and frequency on the inflammation ulcerative colitis. Five groups, each comprising 7 male Wistar albino rats, were formed viz. Colitis (as a control), High sucrose diet + Colitis, High sucrose diet + Intermittent fasting + Colitis, High fat diet + Colitis, High fat diet + Intermittent fasting + Colitis. The intermittent fasting group (experimental group) was not fed for 2 days (non-consecutive) in a week (except water), otherwise fed with ad libitum. Following the 7-wk feeding application, the rats were treated with intrarectal administration of 4% acetic acid (pH 2.4). After the rats were sacrificed, the levels of interleukin-1β, insulin, C-reactive protein, leptin, tumor necrosis factor-α, interleukin-6, insulin-like growth factor-1 and adiponectin were analyzed from the blood samples. Analyzes of results revealed a statistically significant decrease in interleukin-1β, C-reactive protein, tumor necrosis factor-α, interleukin-6 and adiponectin levels in High sucrose diet + Intermittent fasting + Colitis and High fat diet + Intermittent fasting + Colitis groups (P |
|
Date |
2023-05-01T07:05:29Z
2023-05-01T07:05:29Z 2023-05 |
|
Type |
Article
|
|
Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61826 https://doi.org/10.56042/ijeb.v61i05.853 |
|
Language |
en
|
|
Publisher |
NIScPR-CSIR, India
|
|
Source |
IJEB Vol.61(05) [May 2023]
|
|