Severe heart failure with rapid arrhythmia: Treatment with amiodarone and esmolol and its effect on TGF-β1, APN and PIIINP
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Title |
Severe heart failure with rapid arrhythmia: Treatment with amiodarone and esmolol and its effect on TGF-β1, APN and PIIINP
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Creator |
Dai, Jin
Xu, Qingyun Xu, Xiaoming Li, Bo Zhou, Xinbin Chen, Shenjie |
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Subject |
Adiponectin
Anti-arrhythmic drug Blood pressure Cardiac index Heart rate Mean arterial pressure Procollagen Transforming growth factor-β1 |
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Description |
315-319
Rapid arrhythmia (RA) is a major complication of severe heart failure (SHF). Treatment with anti-arrhythmic drug amiodarone though improves the myocardial blood supply and suppress arrhthmia, its clinical application is not satisfactory. Amiodarone combined with another class II antiarrhythmic drug esmolol shows rapid onset and good efficacy. Here, we studied the effects of amiodarone and esmolol in severe heart failure (SHF) with rapid arrhythmia (RA) and its effect on TGF-β1, APN and PIIINP. A total of 180 SHF patients with RA treated at Zhejiang Provincial Hospital of Traditional Chinese Medicine were selected and divided into experimental group (n = 90) and control group (n = 90) according to the random number table method. The control group was given routine therapy + amiodarone therapy, and the experimental group was given routine therapy + amiodarone + esmolol therapy. Cardiac function measures including cardiac index (CI), mean arterial pressure (MAP) and ejection fraction (LVEF), diastolic blood pressure (DBP), systolic blood pressure (SBP) and heart rate (HR), serum TGF-β1, APN and PIIINP levels were observed in both groups before and 48 h after treatment. After treatment, the CI, MAP and LVEF of the experimental group were greater than those of the control group (P |
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Date |
2023-05-01T07:29:35Z
2023-05-01T07:29:35Z 2023-05 |
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Type |
Article
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Identifier |
0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61831 https://doi.org/10.56042/ijeb.v61i05.855 |
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Language |
en
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Publisher |
NIScPR-CSIR, India
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Source |
IJEB Vol.61(05) [May 2023]
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