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Severe heart failure with rapid arrhythmia: Treatment with amiodarone and esmolol and its effect on TGF-β1, APN and PIIINP

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Title Severe heart failure with rapid arrhythmia: Treatment with amiodarone and esmolol and its effect on TGF-β1, APN and PIIINP
 
Creator Dai, Jin
Xu, Qingyun
Xu, Xiaoming
Li, Bo
Zhou, Xinbin
Chen, Shenjie
 
Subject Adiponectin
Anti-arrhythmic drug
Blood pressure
Cardiac index
Heart rate
Mean arterial pressure Procollagen
Transforming growth factor-β1
 
Description 315-319
Rapid arrhythmia (RA) is a major complication of severe heart failure (SHF). Treatment with anti-arrhythmic drug
amiodarone though improves the myocardial blood supply and suppress arrhthmia, its clinical application is not satisfactory.
Amiodarone combined with another class II antiarrhythmic drug esmolol shows rapid onset and good efficacy. Here, we
studied the effects of amiodarone and esmolol in severe heart failure (SHF) with rapid arrhythmia (RA) and its effect on
TGF-β1, APN and PIIINP. A total of 180 SHF patients with RA treated at Zhejiang Provincial Hospital of Traditional
Chinese Medicine were selected and divided into experimental group (n = 90) and control group (n = 90) according to the
random number table method. The control group was given routine therapy + amiodarone therapy, and the experimental
group was given routine therapy + amiodarone + esmolol therapy. Cardiac function measures including cardiac index (CI),
mean arterial pressure (MAP) and ejection fraction (LVEF), diastolic blood pressure (DBP), systolic blood pressure (SBP)
and heart rate (HR), serum TGF-β1, APN and PIIINP levels were observed in both groups before and 48 h after treatment.
After treatment, the CI, MAP and LVEF of the experimental group were greater than those of the control group (P
 
Date 2023-05-01T07:29:35Z
2023-05-01T07:29:35Z
2023-05
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscpr.res.in/handle/123456789/61831
https://doi.org/10.56042/ijeb.v61i05.855
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJEB Vol.61(05) [May 2023]