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Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats

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Title Experimental studies on immunosuppressive effects of peste des petits ruminants (PPR) virus in goats
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Creator Not Available
K K Rajak
B P Sreenivasa
M Hosamani
R P Singh
S K Singh
R K Singh
S K Bandyopadhyay
 
Subject peste des petits ruminants
PPR
VIRUS
GOATS
 
Description Not Available
Effect of virulent and attenuated peste des petits ruminants (PPR) virus on the immune response to nonspecific antigen (ovalbumin) was investigated. Clinical and serological responses were monitored in goats administered with ovalbumin concurrently with either PPR vaccine or virulent virus. Study showed that PPR virulent virus causes marked immunosuppression as evidenced by leukopenia, lymphopenia, and reduced early antibody response to both specific and nonspecific antigen. These observations were predominant particularly during acute phase of disease (4-10 days post-infection). On the other hand, the vaccine virus induced only a transient lymphopenia without significantly affecting the immune response to nonspecific antigen or to itself during this period. Further, the antibody levels to ovalbumin in the group administered with virulent PPRV increased significantly between days 28 and 35 post-infection in comparison to the titers in other two groups given with either ovalbumin alone or in combination with vaccine.
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Date 2023-05-02T06:00:38Z
2023-05-02T06:00:38Z
2005-01-01
 
Type Journal
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/76931
 
Language English
 
Relation Not Available;
 
Publisher Not Available