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Development and characterization of natural polyelectrolyte capsules for drug delivery applications

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Title Development and characterization of natural polyelectrolyte capsules for drug delivery applications
 
Creator Shukaili, S A Al
Devi, M Geetha
Hashmi, R S Al
Fairuz, R F Yousuf
 
Subject Antibacterial drug
Carboxy methyl cellulose
Chitosan
Colloidal particles
Drug delivery
 
Description 379-384
Nanotechnology has provided numerous cutting-edge applications in drug delivery, biosensors, nanorobots, biomedical
devices and nanocarriers. Polyelectrolyte mediated nanocapsules contributes a significant development as drug carriers for
more than a decade. Majority of the nanocapsules employed in the drug delivery system are fabricated using synthetic
materials leading to many health complications. In this research, natural polyelectrolyte capsules are prepared using carboxy
methyl cellulose (CMC) and chitosan by dip coating technique. The capsules are used for the delivery of antibacterial drug
by encapsulating ciprofloxacin hydrochloride into the capsule interiors. The drug release study has been carried out by
altering the permeability of the capsule shell. The optimal pH for the drug encapsulation has been established at 2.3 pH and
381 μg of drug is loaded in 60 min. The drug release study is performed at three different pH conditions of 2.0 pH,
6.0 pH, and 7.2 pH respectively and the release media chosen is water and PBS. Maximum amount of drug release (367 μg)
is achieved at pH 2.0 within 48 hours. The study demonstrates an easy and effective delivery of antibacterial drug from
natural polyelectrolyte capsules.
 
Date 2023-05-04T11:15:03Z
2023-05-04T11:15:03Z
2023-05
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/61844
https://doi.org/10.56042/ijct.v30i3.70107
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.30(3) [May 2023]