Record Details

Carboxymethylated gum tragacanth crosslinked poly(sodium acrylate)hydrogel: Fabrication, characterization, rheology and drug-delivery application

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Carboxymethylated gum tragacanth crosslinked poly(sodium acrylate)hydrogel: Fabrication, characterization, rheology and drug-delivery application
 
Creator Tanwar, Meenakshi
Gupta, Rajinder K
Rani, Archna
 
Subject Astragalus gummifer
Carboxymethylation
Drug-delivery
Hydrogel
Polysaccharides
 
Description 308-319
This study aimed to synthesize Carboxymethylated Gum Tragacanth (CMGT) from the Gum Tragacanth (GT).
Modified gum’s potential as a drug delivery carrier has been explored by synthesizing CMGT based hydrogels. The
viscoelastic characteristics of the fabricated hydrogel have been examined by Rheological analysis. SEM studies have been
conducted to examine the surface morphology and TGA is used to perform the thermal analysis. XRD, FTIR, and solid state
13C NMR have been used to examine the structural features of the GT, CMGT, sodium acrylate based hydrogel (SAH) and
carboxymethylated gum tragacanth co-polymerized with sodium acrylate based hydrogel (CMGT-co-SAH). The
anti-inflammatory drug, Aceclofenac Sodium(AFS) loaded onto the hydrogel has been used as a model drug. The AFS
follows the Fickian mechanism of diffusion and the results are best fitted in Higuchi and Korsmeyer–Peppas models.
 
Date 2023-05-04T11:35:15Z
2023-05-04T11:35:15Z
2023-05
 
Type Article
 
Identifier 0975-0991 (Online); 0971-457X (Print)
http://nopr.niscpr.res.in/handle/123456789/61851
https://doi.org/10.56042/ijct.v30i3.70100
 
Language en
 
Publisher NIScPR-CSIR, India
 
Source IJCT Vol.30(3) [May 2023]