Early-Life Intervention of Lactoferrin and Probiotic in Suckling Piglets: Effects on Immunoglobulins, Intestinal Integrity, and Neonatal Mortality.
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Title |
Early-Life Intervention of Lactoferrin and Probiotic in Suckling Piglets: Effects on Immunoglobulins, Intestinal Integrity, and Neonatal Mortality.
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Creator |
Sarkar, V. K., De, U. K., Kala, A., Verma, A. K., Chauhan, A., Paul, B. R., Soni, S., Gandhar, J. S., Chaudhuri, P., Patra, M. K., Eregowda, C. G., & Gaur, G. K.
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Subject |
lactoferrin, pig, probiotic
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Description |
Not Available
The aim of this study was to determine the effects of early-life bovine lactoferrin and host specific probiotic interventions on growth performance, mortality, and concentrations of immunoglobulin A and immunoglobulin G and transforming growth factor beta 1 (a marker of intestinal integrity) in serum of neonatal piglets. A total of eight piglet litters from parity matched sows were randomly divided into four groups and assigned to one of the four interventions: control (sterile normal saline), bovine lactoferrin (100 mg bovine lactoferrin), probiotic (1 × 109 colony forming unit (cfu) of swine origin Pediococcus acidilactici FT28 probiotic), and bovine lactoferrin + probiotic (100 mg bovine lactoferrin and 1 × 109 CFU of P. acidilactici FT28 probiotic). All the interventions were given once daily through oral route for first 7 days of life. The average daily gain (p = 0.0004) and weaning weight (p < 0.0001) were significantly improved in the probiotic group. The piglet survivability was significantly higher in bovine lactoferrin and probiotic groups than control group in Log-rank (Mantel-Cox) test. The concentrations of immunoglobulin A on day 21 in bovine lactoferrin, probiotic, and bovine lactoferrin + probiotic groups increased significantly (p < 0.05). Immunoglobulin G concentrations on day 7 and 15 in bovine lactoferrin and bovine lactoferrin + probiotic groups and on day 15 in probiotic group were significantly (p < 0.05) elevated, whereas, the concentration of transforming growth factor-β1 was significantly (p < 0.05) increased from day 7 to 21 in all the supplemented groups. In conclusion, the early-life bovine lactoferrin and P. acidilactici FT28 probiotic interventions reduced the mortality in the suckling piglets by promoting the systemic immunity and enhancing the intestinal integrity. Not Available |
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Date |
2023-05-10T04:09:52Z
2023-05-10T04:09:52Z 2023-02-23 |
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Type |
Research Paper
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Identifier |
Sarkar, V. K., De, U. K., Kala, A., Verma, A. K., Chauhan, A., Paul, B. R., Soni, S., Gandhar, J. S., Chaudhuri, P., Patra, M. K., Eregowda, C. G., & Gaur, G. K. (2023). Early-Life Intervention of Lactoferrin and Probiotic in Suckling Piglets: Effects on Immunoglobulins, Intestinal Integrity, and Neonatal Mortality. Probiotics and antimicrobial proteins, 15(1), 149–159.
https://doi.org/10.1007/s12602-022-09964-y http://krishi.icar.gov.in/jspui/handle/123456789/76990 |
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Language |
English
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Relation |
Not Available;
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Publisher |
Springer
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