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Controlled Crystallization of Acetazolamide from Aqueous Polymeric Solutions for Enhancing Dissolution Rate: Application of Statistical Moment Theory and Molecular Docking

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Title Controlled Crystallization of Acetazolamide from Aqueous Polymeric Solutions for Enhancing Dissolution Rate: Application of Statistical Moment Theory and Molecular Docking
 
Creator Sahoo, Rudra Narayan
Dash, Rasmita
Nandi, Souvik
Bose, Anindya
Si, Sudam Chandra
Mallick, Subrata
 
Subject Carboxymethyl cellulose
Hydroxypropyl methylcellulose
Methylcellulose
Polyvinyl alcohol
Solubility improvement
 
Description 515-521
Presence of additives in crystallization process in a controlled manner can lead to different crystal morphologies which
could have a favourable impact on drug dissolution rate. Four different hydrophilic polymers (methylcellulose,
hydroxypropyl methylcellulose, polyvinyl alcohol, and carboxymethyl cellulose) were used for the controlled crystallization
of acetazolamide (ACZ) by solvent evaporation technique. Crystal imperfections of ACZ occurred in the lattice of growing
crystal when crystallized from aqueous polymeric solution and evaluated using both the traditional Full Width at Half
Maximum (FWHM) () and statistical mean value of the XRD peak width (). Crystal imperfection has brought about
significant improvement in the dissolution of newly produced acetazolamide crystals. ACZ crystal produced in presence of
Hydroxypropyl methylcellulose (AHPMC) showed crystal imperfection to the maximum extent and also the greatest
dissolution of the drug was noticed from AHPMC compared to other crystals. Statistical mean value of the peak width of
XRD data as the error-free technique has been utilized successfully for estimating crystallite properties of acetazolamide
crystallized from ethanol as solvent and aqueous polymeric solution as anti-solvent. Crystallite properties using traditional
Full Width Half Maxima method and the error-free Statistical Moment Analysis were compared. This controlled
crystallization technique could be utilized in the design and development of formulation for improved solubility and
bioavailability of the drug.
 
Date 2023-05-09T08:35:51Z
2023-05-09T08:35:51Z
2023-05
 
Type Article
 
Identifier 0022-4456 (Print); 0975-1084 (Online)
http://nopr.niscpr.res.in/handle/123456789/61863
https://doi.org/10.56042/jsir.v82i05.1080
 
Language en
 
Publisher NIScPR-CSIR,India
 
Source JSIR Vol.82(05) [May 2023]