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Impact of geographical location on the polyphenolic content of Nigella sativa seed extract and the relative anti-inflammatory and antioxidant potential thereof: A comparative study

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Title Impact of geographical location on the polyphenolic content of Nigella sativa seed extract and the relative anti-inflammatory and antioxidant potential thereof: A comparative study
 
Creator Rini, Singhal
Shweta, Verma
Vijender, Singh
Sakshi, Bajaj
 
Subject Anti-inflammatory
Antioxidant
Fennel flower
Nigella sativa
Polyphenols
 
Description 89-96
The herb Nigella sativa belonging to the family Ranunculaceae is a well-investigated plant that has a wide range of
pharmacological effects. The study aimed to evaluate and compare the antioxidant and anti-inflammatory potential as well
as phytochemical screening in terms of total phenolic and flavonoid content of N. sativa seeds collected from various
locations in India to establish the impact of geographical location on phytoconstituents of the seeds. The total phenolic and
flavonoid content in methanolic extracts were evaluated using the Folin-ciocalteu reagent and AlCl3 colourimetric method
respectively. The antioxidant activities of the extracts were evaluated using the DPPH method, while the anti-inflammatory
activity of the extracts was determined in vitro using the bovine serum albumin denaturation assay. The extract of the seed
from Vizag had the highest concentration of polyphenols, followed by those from Madhya Pradesh and Punjab. The study
confirmed variations in the quantity of the phytoconstituents of N. sativa seeds of different geographical origins and their
consequential impact on the antioxidant and anti-inflammatory activity indicating that the geographical location exerts a
vital effect on the same.
 
Date 2023-05-11T09:56:45Z
2023-05-11T09:56:45Z
2023-05
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61897
https://doi.org/10.56042/ijnpr.v14i1.1132
 
Language en
 
Relation A61K 36/00
A61K 36/71
A61K 131/00
A61P 29/00
A61P 39/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [March 2023]