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Synthesis, characterization and antibiotic capabilities of microspheres loaded with essential oils

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Title Synthesis, characterization and antibiotic capabilities of microspheres loaded with essential oils
 
Creator Asha, Choudhary
Usha, Rani
Kumar, Salar Raj
Rajesh, Thakur
 
Subject DPPH Assay
Essential oil
Fumigant toxicity
Microspheres
 
Description 81-88
The purpose of the current work was to synthesize, describe, and assess the antimicrobial properties of microspheres against
diverse microorganisms such as Bacillus subtilis, Pseudomonas aeruginosa, and Aspergillus niger. The production of polymeric
microspheres using essential oils, as well as testing the impact of such microspheres on several biological properties was carried
out. The ionic gelation approach was used in the laboratory to create CEO-loaded polymeric microspheres, which were then
improved for use in subsequent experiments and characterized by Particle Size Analyzer, Scanning Electron Microscopy, and
Transmission Electron Microscopy. The DPPH Assay and antibacterial activities were used to enhance the study of polymeric
microspheres loaded with essential oils. Additionally, to observe the per cent encapsulation efficacy, synthetic microspheres
have been used. Microspheres obtained during the experimental process were in size ranging from 80 to 290 nm, depending on
the amount of drugs and polymers contained. Microspheres could be spherical in shape and aggregations at specific sites,
according to SEM and transmission electron microscopy. The range of encapsulation efficiency for various concentrations was
6 to 25%. By using the DPPH assay, it was observed that the antioxidant activity lies between 28 to 64%. When anti-microbial
activities were performed it was observed that the incorporation of essential oils into polymers showed tremendous potential
against microbes. In the current research, the essential oils-loaded polymeric microspheres showed a significant impact on a
variety of microorganisms. Additionally, these microspheres exhibited noticeable radical scavenging activities. In summary, it
may be claimed that certain physiochemical alterations can be used to leverage the diverse activities of these microspheres for
experimental uses in the future.
 
Date 2023-05-11T09:59:49Z
2023-05-11T09:59:49Z
2023-05
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61898
https://doi.org/10.56042/ijnpr.v14i1.1130
 
Language en
 
Relation A61K 36/00
A61K 36/23
A61P 31/00
A61P 39/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [March 2023]