Record Details

Study of drug-like characteristics of bioactive compounds identified from Dicranella pseudosubulata Müll. Hal. ex Gangulee

NOPR - NISCAIR Online Periodicals Repository

View Archive Info
 
 
Field Value
 
Title Study of drug-like characteristics of bioactive compounds identified from Dicranella pseudosubulata Müll. Hal. ex Gangulee
 
Creator Mossang, Pherkop
Chimyang, Nonya
Shankar, Vinay
Uniyal, P. L.
Mangangcha, Irengbam Rocky
Evelin, Heikham
 
Subject Bioactive compounds
Dicranella pseudosubulata
GC-MS analysis
Molecular docking
Moss
 
Description 55-66
Dicranella pseudosubulata Müll Hal. ex Gangulee is a moss species and a member of the Dicranaceae family, which is
known to harbour many secondary metabolites of therapeutic importance. A gas chromatography-mass spectrometry
(GC-MS) analysis of the methanolic extract of D. pseudosubulata was obtained to determine the metabolites of the moss.
The chromatogram revealed 48 compounds, of which four compounds showed the highest concentrations, constituting
73.86% of all the bioactive chemicals detected. The compound d-Glucitol, 1-O-heptyl- showed the highest area percentage
of 45.70 per cent. Other compounds with high concentrations are 9,12-Octadecadienoic acid (Z,Z)-, TMS derivative
(13.35%); Palmitic acid, TMS derivative (9.46%) and Butanoic acid, 4-[(trimethylsilyl)oxy]-, trimethylsilyl ester (5.35%).
These metabolites were then examined for their drug-like characteristics using SwissADME and predicted for potential
target proteins using SwissTargetPrediction tools. Molecular docking analyses with the most probable targets of d-Glucitol,
1-O-heptyl-;9,12-octadecadienoic acid; Palmitic acid, TMS derivative and Butanoic acid, 4-[(trimethylsilyl)oxy]-,
trimethylsilyl ester with Beta-glucocerebrosidase (GBA), Peroxisome proliferator-activated receptor gamma (PPARG), fatty
acid binding protein (FABP4) and Thymidylate synthase (TYMS), respectively, showed thermodynamically favourable
bindings. The target proteins have been reported to be associated with various ailments and their inhibition by these
compounds is necessary to control and maintain cell growth in several cancers as well as in treating malaria and leishmania,
obesity, lipidosis, kidney necrosis, liver carcinoma, insulin resistance etc. Some of the compounds have been reported to
exhibit antimicrobial, antioxidant, and hepatoprotective activities. Thus, the finding suggests that D. pseudosubulata could
serve as a potential therapeutic drug against various diseases.
 
Date 2023-05-11T10:14:38Z
2023-05-11T10:14:38Z
2023-05
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61901
https://doi.org/10.56042/ijnpr.v14i1.1125
 
Language en
 
Relation A61K 36/00, A61K 36/10
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [March 2023]