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Elucidation of drug-like properties in metabolites of Curcuma angustifolia Roxb

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Title Elucidation of drug-like properties in metabolites of Curcuma angustifolia Roxb
 
Creator Mangangcha, Irengbam Rocky
Shankar, Vinay
Evelin, Heikham
 
Subject Arbuscular mycorrhizal fungi
Curcuma angustifolia
Drugs
Metabolites
Therapeutic potential
 
Description 37-49
The plant, Curcuma angustifolia Roxb., belonging to the family Zingiberaceae was subjected to a pot experiment to
study the effects of arbuscular mycorrhizal fungi (AMF) on its metabolome. The experiment consisted of two treatments:
Mycorrhizal (M), C. angustifolia plants inoculated with a consortium of AMF and non-mycorrhizal control plants (NM),
plants not inoculated with AMF. GC-MS analyses revealed that AMF colonization modulated the composition and
concentration of metabolites in different plant parts, leaves, rhizomes and roots as compared to their respective NM
counterparts. However, n-hexadecanoic acid, 5-Hydroxymethylfurfural, 9, 12-octadecadienoic acid and terpineol were
observed in all the parts in higher percentages. Cis-vaccenic acid was found in the highest concentration in rhizomes while
roots showed a high concentration of coronarin E. These metabolites were found to possess good characteristics of being
therapeutic drugs and their predicted targets are involved in different diseases such as obesity, diabetes mellitus,
hypertension, cancers, etc. They also have many structurally similar compounds to the metabolites which are active against
various protein targets involved in different diseases. Among them, terpineol has the Androgen receptor (AR) as the highest
probable target whose roles have been reported in several cancers, especially prostate cancer. AR showed a
thermodynamically favourable binding affinity with terpineol (ΔG = -6.2 kcal/mol). Similarly, other metabolites also
showed binding affinities with their predicted targets. Thus, in the study, we report various metabolites of C. angustifolia
and their potential characteristic drug-like properties, which may serve as a green alternative for better health care to
mankind.
 
Date 2023-05-11T10:25:10Z
2023-05-11T10:25:10Z
2023-05
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61903
https://doi.org/10.56042/ijnpr.v14i1.1126
 
Language en
 
Relation A61K 36/00
A61K 36/9062
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [March 2023]