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Role of green tea catechins in modulating stromal-epithelial interaction in prostate cells

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Title Role of green tea catechins in modulating stromal-epithelial interaction in prostate cells
 
Creator Devi, Nandana
Nagesh, A Muni
Jala, Moses Azaraiah
Gupta, Surabhi
Chaturvedi, Pradeep Kumar
Kumar, Neeraj
Sandeep, Kumar
Pandey, Deepak
 
Subject BPH
Catechin
Flavonoid
Prostate
Sex steroids
Stromal-epithelial interaction
 
Description 28-36
Recent years have witnessed a significant interest in phytonutrients as treatment module for a range of diseases,
including cancers. Catechins, predominant in green tea are potent antioxidants belonging to the flavonoid family that have
been linked epidemiologically to a lower prevalence of prostate pathologies in Asian nations. In the present work, we
investigated ameliorative potential of green tea catechins (epigallocatechin, EGC, and epigallocatechin 3-gallate, EGCG) on
the aberrant proliferation of normal prostate epithelial cells driven by paracrine action of stromal medium, conditioned with
estradiol (E2) and dihydrotestosterone (DHT) (20 pM and 10 nM respectively). It was observed that EGC (5 μM)
significantly inhibited the aberrant epithelial proliferation induced by stromal conditioned medium (CM), with a decreased
expression of ERα, ERβ, AR, CK05, CK18, and PSA. Further, the CM collected after pre-treatment of stromal cells with
EGCG (0.75 μM), had an inhibitory effect on epithelial cell proliferation, with reduction in the expression of ERα, AR, and
CK05 while the expression of ERβ, CK18, and PSA were increased. These findings suggest that EGC helps in
downregulating the aberrant epithelial proliferation while EGCG is able to downregulate the proliferative potential of
stromal cell secretome. These insights will help in deciphering preventive measures against prostate pathologies involving
stromal-epithelial cross-talk.
 
Date 2023-05-11T10:29:30Z
2023-05-11T10:29:30Z
2023-05
 
Type Article
 
Identifier 0976-0512 (Online); 0976-0504 (Print)
http://nopr.niscpr.res.in/handle/123456789/61904
https://doi.org/10.56042/ijnpr.v14i1.1136
 
Language en
 
Relation A61K 36/00
 
Publisher NIScPR-CSIR,India
 
Source IJNPR Vol.13(4) [March 2023]