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Gonadotropin inhibitory hormone receptors (GnIHRs): Molecular characterization and synergistic effect of different drugs in Indian major carp, Labeo catla

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Title Gonadotropin inhibitory hormone receptors (GnIHRs): Molecular characterization and synergistic effect of different drugs in Indian major carp, Labeo catla
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Creator Kumar P*, Wisdom KS, Ram RK, Gireesh-Babu P, Nayak SK, Nagpure NS, Sharma R
 
Subject GnIHRs RF313 Melatonin LHRHa Reproduction
 
Description Not Available
After the discovery of Gonadotropin-inhibitory hormone (GnIH) in birds in 2000, it showed different roles in different vertebrate classes and even in different species of same classes. In birds and mammals, GnIH inhibits the expression of gonadotropins during reproduction, while in fishes it exerts both inhibitory and stimulatory effect
on reproduction. The current study evaluates the role of GnIH during reproduction in Labeo catla. The partial cDNA sequence of GnIHR1 and GnIHR3 receptor genes was identified by degenerate PCR. The mRNA expression analysis of GnIHRs during different reproductive phases showed that the expression of all three GnIH receptor
genes is highest during spawning phase. The expression of GnIH receptors is detected in both brain and gonads except for GnIHR3 which only expressed in gonads. The in vivo experiments with GnIH antagonist, RF313 drastically reduced the expression level of reproduction related genes like LH, FSH, and GnRH at 1 h post- injection. In another experiment the surge induced by cGnIH-III peptide on gonadotropins gene expression is
further increased when co-injected with LHRHa. However, co-injection of melatonin along with cGnIH-III pep- tide had opposite effects. These results showed that the GnIH/GnIHRs system has positive effect on reproduction in L. catla.
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Date 2023-05-12T03:56:21Z
2023-05-12T03:56:21Z
2021-09-01
 
Type Research Paper
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/77110
 
Language English
 
Relation Not Available;
 
Publisher ELSEVIER