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Adjuvantation of inactivated Foot and Mouth Disease Virus vaccine with IL-15 expressing plasmid improves the immune response in Guinea Pigs

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Title Adjuvantation of inactivated Foot and Mouth Disease Virus vaccine with IL-15 expressing plasmid improves the immune response in Guinea Pigs
Not Available
 
Creator Nagaraj V
John L
Bharatiraja S
H.J. Dechamma
G. R. Reddy
 
Subject Bovine Interleukin 15 (bIL-15)
Foot and Mouth Disease Virus
PLG micro particles
Immune response
 
Description Not Available
Foot and mouth disease is a highly contagious disease affecting cloven footed animals. Vaccination using inactivated virus is followed to control the disease. As the immune response conferred by the inactivated vaccine is short lived, there is a need for an alternate vaccine with increased duration of immunity. Inclusion of adjuvant which enhances B and T cell responses is one of the strategies to increase the duration of immune responses of the vaccine. Interleukin 15 is one such a cytokine which improves the cell mediated immune response and also involved in the maintenance of memory T and B cells. In the present communication, we evaluated the role of bovine IL-15 as an adjuvant to inactivated FMD vaccine in guinea pig model. Animals injected with FMD inactivated vaccine and IL-15 plasmid showed improved levels of neutralizing antibodies which were maintained up to 6 months (as the level of neutralizing antibodies is more >1.5 which is considered to give protection). Increased Th1 and Th2 responses (by measuring the level of IL-4 and IFN- gamma responses) were seen in IL-15 adjuvanted guinea pigs compared to animals injected with inactivated vaccine alone.
Not Available
 
Date 2023-05-12T03:30:32Z
2023-05-12T03:30:32Z
2017-09-01
 
Type Research Paper
 
Identifier Nagaraj V, John L, Bharatiraja S, Dechamma HJ, Reddy GR. Adjuvantation of inactivated Foot and Mouth Disease Virus vaccine with IL-15 expressing plasmid improves the immune response in Guinea Pigs. Biologicals. 2017 Sep;49:23-27. doi: 10.1016/j.biologicals.2017.07.005. Epub 2017 Jul 19. PMID: 28734743.
1045-1056
http://krishi.icar.gov.in/jspui/handle/123456789/77089
 
Language English
 
Relation Not Available;
 
Publisher ELSEVIER