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Host serum microRNA profiling during early stage of foot-and-mouth disease virus infection

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Title Host serum microRNA profiling during early stage of foot-and-mouth disease virus infection
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Creator S H Basagoudanavar
M Hosamani
R P Tamil Selvan
B P Sreenivasa
A Sanyal
R Venkataramanan
 
Subject Foot-and-mouth disease virus
microRNA profiling
virus infection
 
Description Not Available
Foot-and-mouth disease virus (FMDV) causes a highly contagious infection in cloven-hoofed animals, with many outbreaks in the developing world. MicroRNAs (miRNAs) are non-coding RNAs that regulate antiviral defence by post-transcriptional regulation of gene expression. In this study, the host miRNA response following FMDV infection was investigated in cattle, a natural host for FMDV. A significant alteration in serum miRNA expression was detected at early stages of infection. Compared to prior to infection, on day 2 postinfection (PI), 119 miRNAs were upregulated, of which 39 were significantly upregulated (P < 0.05). Gene target prediction and pathway enrichment analysis suggested that upregulated miRNAs target innate immune signalling pathways, suggesting a homeostasis effect, possibly to limit inappropriate immune responses. Further, for the significantly upregulated miRNAs, nine miRNA recognition elements were identified in the genome sequence of FMDV serotype O, which was used for infection. The antiviral effect of four of these miRNAs was confirmed in a cell culture system. These data demonstrate that changes in miRNA expression occur during early pathogenesis, and the identification of possible miRNA targets genes could help in elucidating molecular events involved in virus-host interaction and thus could be useful in developing therapeutic strategies.
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Date 2023-05-12T03:53:27Z
2023-05-12T03:53:27Z
2018-04-03
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77106
 
Language English
 
Relation Not Available;
 
Publisher Archives of Virology