Record Details

Growth kinetics and immune response of chimeric foot-and-mouth disease virus serotype 'O' produced through replication competent mini genome of serotype Asia 1, 63/72, in BHK cell lines

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Growth kinetics and immune response of chimeric foot-and-mouth disease virus serotype 'O' produced through replication competent mini genome of serotype Asia 1, 63/72, in BHK cell lines
Not Available
 
Creator Joshi R
S. Chandrasekar
Soumya Paul
Ashok Kumar Chokkalingam
T. Saravanan
Kakoli Ahmad
H.J. Dechamma
G.R. Reddy
S.M. Gopinath
D.N. Das
M.S. Shaila
G.N. Bharath
V.V.S. Suryanarayana
 
Subject Foot-and-mouth disease
Vaccine
Chimeric virus
Vaccine strain
FMDV minigenome
 
Description Not Available
Regular vaccinations with potent vaccine, in endemic countries and vaccination to live in non-endemic countries are the methods available to control foot-and-mouth disease. Selection of candidate vaccine strain is not only cumbersome but the candidate should grow well for high potency vaccine preparation. Alternative strategy is to generate an infectious cDNA of a cell culture-adapted virus and use the replicon for development of tailor-made vaccines. We produced a chimeric ‘O’ virus in the backbone of Asia 1 and studied its characteristics. The chimeric virus showed high infectivity titre (>1010) in BHK 21 cell lines, revealed small plaque morphology and there was no cross reactivity with antiserum against Asia 1. The virus multiplies rapidly and reaches peak at 12 h post infection. The vaccine prepared with this virus elicited high antibody titres.
Not Available
 
Date 2023-05-12T04:16:48Z
2023-05-12T04:16:48Z
2013-05-01
 
Type Research Paper
 
Identifier Joshi R, Chandrasekar S, Paul S, Chokkalingam AK, Saravanan T, Ahmad K, Dechamma HJ, Reddy GR, Gopinath SM, Das DN, Shaila MS, Bharath GN, Suryanarayana VV. Growth kinetics and immune response of chimeric foot-and-mouth disease virus serotype 'O' produced through replication competent mini genome of serotype Asia 1, 63/72, in BHK cell lines. Virus Res. 2013 May;173(2):299-305. doi: 10.1016/j.virusres.2013.01.018. Epub 2013 Feb 4. PMID: 23384973.
0168-1702
http://krishi.icar.gov.in/jspui/handle/123456789/77160
 
Language English
 
Relation Not Available;
 
Publisher ELSEVIER