Growth kinetics and immune response of chimeric foot-and-mouth disease virus serotype 'O' produced through replication competent mini genome of serotype Asia 1, 63/72, in BHK cell lines
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Title |
Growth kinetics and immune response of chimeric foot-and-mouth disease virus serotype 'O' produced through replication competent mini genome of serotype Asia 1, 63/72, in BHK cell lines
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Creator |
Joshi R
S. Chandrasekar Soumya Paul Ashok Kumar Chokkalingam T. Saravanan Kakoli Ahmad H.J. Dechamma G.R. Reddy S.M. Gopinath D.N. Das M.S. Shaila G.N. Bharath V.V.S. Suryanarayana |
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Subject |
Foot-and-mouth disease
Vaccine Chimeric virus Vaccine strain FMDV minigenome |
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Description |
Not Available
Regular vaccinations with potent vaccine, in endemic countries and vaccination to live in non-endemic countries are the methods available to control foot-and-mouth disease. Selection of candidate vaccine strain is not only cumbersome but the candidate should grow well for high potency vaccine preparation. Alternative strategy is to generate an infectious cDNA of a cell culture-adapted virus and use the replicon for development of tailor-made vaccines. We produced a chimeric ‘O’ virus in the backbone of Asia 1 and studied its characteristics. The chimeric virus showed high infectivity titre (>1010) in BHK 21 cell lines, revealed small plaque morphology and there was no cross reactivity with antiserum against Asia 1. The virus multiplies rapidly and reaches peak at 12 h post infection. The vaccine prepared with this virus elicited high antibody titres. Not Available |
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Date |
2023-05-12T04:16:48Z
2023-05-12T04:16:48Z 2013-05-01 |
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Type |
Research Paper
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Identifier |
Joshi R, Chandrasekar S, Paul S, Chokkalingam AK, Saravanan T, Ahmad K, Dechamma HJ, Reddy GR, Gopinath SM, Das DN, Shaila MS, Bharath GN, Suryanarayana VV. Growth kinetics and immune response of chimeric foot-and-mouth disease virus serotype 'O' produced through replication competent mini genome of serotype Asia 1, 63/72, in BHK cell lines. Virus Res. 2013 May;173(2):299-305. doi: 10.1016/j.virusres.2013.01.018. Epub 2013 Feb 4. PMID: 23384973.
0168-1702 http://krishi.icar.gov.in/jspui/handle/123456789/77160 |
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Language |
English
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Relation |
Not Available;
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