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Expression of vp1 protein of serotype a and o of foot-and-mouth disease virus in transgenic sunnhemp plants and its immunogenicity for guinea pigs

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Title Expression of vp1 protein of serotype a and o of foot-and-mouth disease virus in transgenic sunnhemp plants and its immunogenicity for guinea pigs
Not Available
 
Creator J. P. Rao
P. Agrawal
R. Mohammad
S. K. Rao
G. R. Reddy
H. J. Dechamma
V. V. S sury¬anarayana
 
Subject foot-and-mouth disease
sunnhemp
Agrobacterium tumefaciens
FMDV-VP1 gene
serotype O and A
in planta transformation
transgenic plants
bivalent vaccine
 
Description Not Available
Recently, transgenic plants expressing immunogenic proteins of foot-and-mouth disease virus (FMDV) have been used as oral or parenteral vaccines against foot-and-mouth disease (FMD). They exhibit advantages like cost effectiveness, absence of processing, thermostability, and easy oral application. FMDV VP1 protein of single serotype has been mostly used as immunogen. Here we report the development of a bivalent vaccine with tandem-linked VP1 proteins of two serotypes, A and O, present in transgenic forage crop Crotalaria juncea. The expression of the bivalent protein in the transgenic plants was confirmed by Western blot analysis. Guinea pig reacted to orally or parenterally applied vaccine by humoral as well as cell-mediated immune responses including serum antibodies and stimulated lymphocytes, respectively. The vaccine protected the animals against a challenge with the virus of serotype A as well as O. This is the first report on the development of a bivalent FMD vaccine using a forage crop.
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Date 2023-05-12T04:32:45Z
2023-05-12T04:32:45Z
2012-01-01
 
Type Research Paper
 
Identifier Rao JP, Agrawal P, Mohammad R, Rao SK, Reddy GR, Dechamma HJ, S Suryanarayana VV. Expression of VP1 protein of serotype A and O of foot-and-mouth disease virus in transgenic sunnhemp plants and its immunogenicity for guinea pigs. Acta Virol. 2012;56(2):91-9. doi: 10.4149/av_2012_02_91. PMID: 22720698.
0001-723X
http://krishi.icar.gov.in/jspui/handle/123456789/77170
 
Language English
 
Relation Not Available;
 
Publisher PubMed Central