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Improved immune response by ID-pVAC: a secretory DNA vaccine construct delivered by PLG micro particles against foot and mouth disease in guinea pigs

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Title Improved immune response by ID-pVAC: a secretory DNA vaccine construct delivered by PLG micro particles against foot and mouth disease in guinea pigs
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Creator Sameer K. Jadav
K. Siva Reddy
B.R. Rashmi
H.J. Dechamma
K. Ganesh
V.V.S. Suryanarayana
G.R. Reddy
 
Subject DNA vaccine
 
Description Not Available
Foot and mouth disease (FMD) outbreaks usually have devastating effects on the economy of countries were disease is endemic due to direct and indirect cost; most of them related to international trade embargoes of animals and animal products. Although currently used inactivated vaccine provides protection, it has several drawbacks like short duration of immunity, and the requirement for containment facilities. A DNA vaccine construct which expresses the secretary antigens, delivered through micro particles could be one of the alternate approaches to overcome these limitations. Present study is envisaged to prepare a DNA vaccine construct containing the VP1 sequence of FMDV serotype O in pVAC vector. DNA vaccine was formulated by adsorbing plasmid DNA construct on cationic micro particles and administered in guinea pigs @25μg DNA vaccine construct per animal intramuscularly. Sera samples collected were analyzed by sandwich ELISA and SNT, shown enhanced immune response in PLG adjuvanted DNA vaccine. MTT and 3H Thymidine incorporation have shown good CMI responses to PLG adjuvanted DNA. When challenged with 100 gpid50 of homologous virus 5 of the six animals were protected.
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Date 2023-05-15T09:26:25Z
2023-05-15T09:26:25Z
2011-08-01
 
Type Research Paper
 
Identifier Jadav SK, Reddy KS, Rashmi BR, Dechamma HJ, Ganesh K, Suryanarayana VVS, Reddy GR. Improved immune response by ID-pVAC: a secretory DNA vaccine construct delivered by PLG micro particles against foot and mouth disease in guinea pigs. Res Vet Sci. 2011 Aug;91(1):86-89. doi: 10.1016/j.rvsc.2010.08.011. Epub 2010 Sep 29. PMID: 20884037.
0034-5288
http://krishi.icar.gov.in/jspui/handle/123456789/77286
 
Language English
 
Relation Not Available;
 
Publisher ELSEVIER