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Induction of antiviral and cell mediated immune responses significantly reduce viral load in an acute foot-and-mouth disease virus infection in cattle.

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Title Induction of antiviral and cell mediated immune responses significantly reduce viral load in an acute foot-and-mouth disease virus infection in cattle.
Not Available
 
Creator S Saravanan
G Neha
H B Ranjitha
B. P. Sreenivasa,
M Hosamani
C Prieto
V Umapathi
H K Santosh
S Behera
V V Dhanesh
G S Krishna
S Gopinathan
A Kolte
A Sanyal
J Bayry
S H Basagoudanavar
 
Subject Foot-and-mouth disease virus
Acute infection
Transcriptome
 
Description Not Available
Foot-and-mouth disease virus (FMDV) causes a severe infection in ruminant animals. Here we present an in-depth transcriptional analysis of soft-palate tissue from cattle experimentally infected with FMDV. The differentially expressed genes from two Indian cattle (Bos indicus) breeds (Malnad Gidda and Hallikar) and Holstein Friesian (HF) crossbred calves, highlighted the activation of metabolic processes, mitochondrial functions and significant enrichment of innate antiviral immune response pathways in the indigenous calves. The results of RT-qPCR based validation of 12 genes was in alignment with the transcriptome data. The indigenous calves showing lesser virus load, elicited early neutralizing antibodies and IFN-γ immune responses. This study revealed that induction of potent innate antiviral response and cell mediated immunity in indigenous cattle, especially Malnad Gidda, significantly restricted FMDV replication during acute infection. These data highlighting the molecular processes associated with host-pathogen interactions, could aid in the conception of novel strategies to prevent and control FMDV infection in cattle.
Not Available
 
Date 2023-05-12T06:12:22Z
2023-05-12T06:12:22Z
2021-11-01
 
Type Article
 
Identifier Not Available
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77199
 
Language English
 
Relation Not Available;
 
Publisher Genomics