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Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen.
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| Title |
Co-administration of flagellin augments immune responses to inactivated foot-and-mouth disease virus (FMDV) antigen.
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| Creator |
Hajam IA, Dar PA, Chandrasekar S, Nanda RK, Kishore S, Bhanuprakash V, Ganesh K.
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| Subject |
Flagellin; Foot-and-mouth disease virus; Guinea pig; Immune response; Molecular adjuvant.
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| Description |
Foot-and-mouth disease virus (FMDV) is one of the most contagious animal virus known that affects livestock health and production. This study aimed to investigate the effect of flagellin, a toll-like receptor 5 agonist, on the immune responses to inactivated FMDV antigen in guinea pig model. Our results showed that the co-administration of flagellin with FMDV antigen through intradermal route induces earlier and higher anti-FMDV neutralizing antibody responses as compared to FMDV antigen alone. Both IgG1 and IgG2 antibody-isotype responses were enhanced, but the IgG1/IgG2 ratios were relatively low, indicative of TH1 type of immune activation. On live viral challenge, flagellin+FMDV immunized guinea pigs showed 70% (7 out of 10) protection rate as compared to 40% (4 out of 10) in FMDV alone immunized guinea pigs. The results demonstrate that the co-administration of flagellin augments immune responses (preferably TH1 type) and protective efficacy against FMDV in guinea pigs.
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| Date |
2023-05-12T10:11:06Z
2023-05-12T10:11:06Z 2013-12-01 |
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| Type |
Research Paper
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| Identifier |
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77223 |
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| Language |
English
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| Publisher |
Elsevier
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