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Analgesic, Antibacterial and Antiviral Activities of 2-(5-Alkyl-1,3,4-oxadiazol-2-yl)-3H-benzo[f]chromen-3-ones.

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Title Analgesic, Antibacterial and Antiviral Activities of 2-(5-Alkyl-1,3,4-oxadiazol-2-yl)-3H-benzo[f]chromen-3-ones.
 
Creator Raghavendra R, Mahadevan KM, Satyanarayan ND, Bhanuprakash V, Venkatesan G, Yogisharadhya R.
 
Subject Analgesic; antibacterial; antiviral; benzo[f]chromen-3-ones-oxadiazoles; buffalopox virus; camelpox virus; photoluminescence.
 
Description A novel series of 2-(5-alkyl-1,3,4-oxadiazol-2-yl)-3H-benzo[f]chromen-3-ones (4a-e) have been evaluated for analgesic, antibacterial and antiviral activities. Analgesic activity was carried out using acetic acid-induced writhing method in Swiss albino male mice. The antibacterial activity was performed against Gram-positive and Gram-negative clinical strains by agar well diffusion method. The in vitro antiviral activity was carried out against camelpox and buffalopox viruses. The analgesic activity exhibited by the compounds 4a, 4c and 4d were found to be more significant compared to the standard. The bacterial activity was determined by the inhibition of growth of the organism by the drugs at different concentrations. All the compounds showed significant activity when compared with the drug ciprofloxacin. The in vitro antiviral activity of the compound 4b tested against camelpox and buffalopox viruses revealed no activity when tested at concentrations of 250 μg. The compound 4b did not alter the titres of both the viruses and the titres remain, respectively, 10(6.5) TCID50 and 10(6.74) TCID50 per ml for camelpox vaccine virus and buffalopox vaccine virus. However, the compounds 4a-e showed significant analgesic and antibacterial activities.
 
Date 2023-05-12T10:20:26Z
2023-05-12T10:20:26Z
2012-07-01
 
Type Research Paper
 
Identifier Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77234
 
Language English
 
Publisher OMICS International, Medknow Publications