Record Details

Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress responses

KRISHI: Publication and Data Inventory Repository

View Archive Info
 
 
Field Value
 
Title Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress responses
Not Available
 
Creator Basavaraj Sajjanar
Rajib Deb
Susheel Kumar Raina
Sachin Pawar
Manoj P Brahmane
Avinash V Nirmale
Nitin P Kurade
Gundallahalli B Manjunathareddy
Santanu Kumar Bal
Narendra Pratap Singh
 
Subject RNA motifs, Stress granules, Stress responses,Translation regulation
 
Description Not Available
Stress is the result of an organism's interaction with environmental challenges. Regulations of gene expression including translation modulations are critical for adaptation and survival under stress. Untranslated regions (UTRs) of the transcripts play significant roles in translation regulation and continue to raise many intriguing questions in our understanding of cellular stress physiology. IRES (Internal ribosome entry site) and uORF (upstream open reading frame) mediated alternative translation initiations are emerging as unique mechanisms. Recent studies have revealed novel means of mRNAs stabilization in stress granules and their reversible modifications. Differential regulation of select transcripts is possible by the interplay between the adenine/uridine-rich elements (AREs) in 3'UTR with their binding proteins (AUBP) and by microRNA-mediated effects. Coordination of these various mechanisms control translation and thereby enables appropriate responses to environmental stress. In this review, we focus on the role of sequence signatures both at 5' and 3'UTRs in translation reprogramming during cellular stress responses.
Not Available
 
Date 2023-05-16T04:15:04Z
2023-05-16T04:15:04Z
2017-04-01
 
Type Review Paper
 
Identifier Sajjanar B, Deb R, Raina SK, Pawar S, Brahmane MP, Nirmale AV, Kurade NP, Manjunathareddy GB, Bal SK, Singh NP. Untranslated regions (UTRs) orchestrate translation reprogramming in cellular stress responses. J Therm Biol. 2017 Apr;65:69-75. doi: 10.1016/j.jtherbio.2017.02.006
Not Available
http://krishi.icar.gov.in/jspui/handle/123456789/77450
 
Language English
 
Relation Not Available;
 
Publisher Springer