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Studies on radioprotective and antiviral activities of some bischalcone derivatives

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Title Studies on radioprotective and antiviral activities of some bischalcone derivatives
 
Creator Darshan Raj CG, Sarojini BK, Bhanuprakash V, Yogisharadhya R, Kumara Swamy BE, Raghavendra R
 
Subject Radioprotection, E. coli, Antioxidants,Bischalcones, Cyclic voltammetric studies, Antiviral activity
 
Description This work reports the cyclic voltammetric,modulatory effect on oxidative stress markers againstradiation induced oxidative stress in E. coli bacteriaand antiviral activities of two bischalcone derivatives(2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene)-cyclo-pentanone (B1) and (2E,5E)-2,5-bis(4-fluorobenzylidene)-cyclopentanone (B2). The reducing ability of B1 and B2was determined by cyclic voltammetry. The anodic peakcurrent ipa and anodic peak potential Epa of B1 and B2were -154.7, -99 lA, and -0.15 V, 0.0125 V, respec-tively. The low anodic current and low anodic peakpotential imply the good reducing ability of the molecules.The radioprotective effect of bischalcones was studied bygamma radiation induced oxidative stress in E. coli K12 at0.2 and 0.4 Gy. The bacteria samples treated with B1 andirradiated showed diminished level of TBARS, an oxida-tive stress marker. The levels of SOD and CAT antioxidantenzymes were brought to near basal level for B1 treatedand irradiated bacteria with respect to the control. Theprotective effect of the bischalcone derivatives againstradiation was further supported by determining colonyforming units (CFU) of bacteria in pre- and post-irradiatedsamples. Further, B2 showed 73.69% of inhibition ofbuffalopox virus and camelpox virus
 
Date 2023-05-16T09:46:33Z
2023-05-16T09:46:33Z
2012-09-01
 
Type Research Paper
 
Identifier http://krishi.icar.gov.in/jspui/handle/123456789/77496
 
Language English
 
Publisher Springer