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Membrane efflux pumps of pathogenic Vibrio species: Role in antimicrobial resistance and virulence.

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Title Membrane efflux pumps of pathogenic Vibrio species: Role in antimicrobial resistance and virulence.
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Creator Not Available
 
Subject antimicrobial resistance; bacteria; cholera; infection; multidrug efflux pump; multidrug resistance.
 
Description Not Available
Infectious diseases caused by bacterial species of the Vibrio genus have had considerable significance upon human health for centuries. V. cholerae is the causative microbial agent of cholera, a severe ailment characterized by profuse watery diarrhea, a condition associated with epidemics, and seven great historical pandemics. V. parahaemolyticus causes wound infection and watery diarrhea, while V. vulnificus can cause wound infections and septicemia. Species of the Vibrio genus with resistance to multiple antimicrobials have been a significant health concern for several decades. Mechanisms of antimicrobial resistance machinery in Vibrio spp. include biofilm formation, drug inactivation, target protection, antimicrobial permeability reduction, and active antimicrobial efflux. Integral membrane-bound active antimicrobial efflux pump systems include primary and secondary transporters, members of which belong to closely related protein superfamilies. The RND (resistance-nodulation-division) pumps, the MFS (major facilitator superfamily) transporters, and the ABC superfamily of efflux pumps constitute significant drug transporters for investigation. In this review, we explore these antimicrobial transport systems in the context of Vibrio spp. pathogenesis and virulence.
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Date 2023-05-16T03:03:06Z
2023-05-16T03:03:06Z
2022-02-07
 
Type Journal
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/77320
 
Language English
 
Relation Not Available;
 
Publisher PubMed