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Reassortment and evolutionary dynamics of tilapia lake virus genomic segments.

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Title Reassortment and evolutionary dynamics of tilapia lake virus genomic segments.
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Creator Not Available
 
Subject Tilapia lake virus (TiLV) Genome Substitution rate Selection Mutation
 
Description Not Available
The tilapia lake virus (TiLV), a highly infectious negative-sense single-stranded segmented RNA virus, has caused
several outbreaks worldwide since its first report from Israel in 2014, and continues to pose a major threat to the
global tilapia industry. Despite its economic importance, little is known about the underlying mechanisms in the
genomic evolution of this highly infectious viral pathogen. Using phylogenomic approaches to the genome se-
quences of TiLV isolates from various geographic regions, we report on the pervasive role of reassortment, se-
lection, and mutation in TiLV evolution. Our findings provided the evidence of genome-wide reassortment in this
newly discovered RNA virus. The rate of non-synonymous (dN) to synonymous (dS) substitutions was less than
one (dN/dS = 0.076 to 0.692), indicating that each genomic segment has been subjected to purifying selection.
Concurrently, the rate of nucleotide substitution for each genomic segment was in the order of 1–3 × 10-3 nucleotide substitutions per site per year, which is comparable to the rate of other RNA viruses. Collectively, in
line with the results of the previous studies, our results demonstrated that reassortment is the dominant force in
the evolution and emergence of this highly infectious segmented RNA virus.
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Date 2023-05-16T03:03:49Z
2023-05-16T03:03:49Z
2021-11-06
 
Type Journal
 
Identifier Not Available
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http://krishi.icar.gov.in/jspui/handle/123456789/77324
 
Language English
 
Relation Not Available;
 
Publisher Elsevier