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Assessment of Indian Rosewood (Dalbergia sissoo) Standardized Leaf Extract on Isoproterenol-Induced Myocardial Injury in Rats

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Title Assessment of Indian Rosewood (Dalbergia sissoo) Standardized Leaf Extract on Isoproterenol-Induced Myocardial Injury in Rats
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Creator Kasa JK, Singh TU, Parida S, Addison MP, Darzi SA, Choudhury S, Kandasa
 
Subject Dalbergia sissoo Isoproterenol Myocardial injury Extract
 
Description Not Available
The present study was undertaken to evaluate the effect of alcoholic extract of Dalbergia sissoo leaf extract (DSE) on isoproterenol (ISP)-induced myocardial injury in rats. Evaluation of three doses (30, 100 and 300 mg/kg of body weight) of DSE was done in ISP-treated rats. ISP was used at 85 mg/kg body weight by subcutaneous route for two subsequent days to induce myocardial injury in rats. Assessment of myocardial injury was done by estimation of different cardiac injury markers like LDH, CK-MB. Serum cholesterol, LDL, HDL, triglycerides in serum, myocardial infarcted area, oxidative stress and histopathology in heart tissue were also assessed in rats. Mean arterial pressure and heart rate were recorded in all the groups. Rats pretreated with DSE (30, 100 and 300 mg/kg of body weight) showed significant (p < 0.05-0.001) improvement in the heart weight/body weight ratio, myocardial infarcted areas, heart rate and mean arterial pressure in ISP-induced myocardial injury. DSE showed significant (p < 0.05-0.001) improvement in serum LDH, CK-MB, cholesterol, LDL and triglyceride levels at all the dose levels. However, DSE pretreatment had no significant effect on serum HDL level. Pretreatment with DSE (30, 100 and 300 mg/kg body weight) showed significant (p < 0.001) reduction in MDA level in comparison with myocardial injured rats. Further, antioxidant potential was also improved in terms of improved activities of reduced glutathione, superoxide dismutase and catalase with the DSE pretreatment. Histopathology also showed significant improvement in heart tissue. The study suggests that DSE showed beneficial effect in ISP-induced myocardial injury in rats.
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Date 2023-05-18T04:50:51Z
2023-05-18T04:50:51Z
2014-11-25
 
Type Article
 
Identifier Kasa JK, Singh TU, Parida S, Addison MP, Darzi SA, Choudhury S, Kandasamy K, Singh V, Dash JR, Shanker K, Mishra SK. Assessment of Indian Rosewood (Dalbergia sissoo) Standardized Leaf Extract on Isoproterenol-Induced Myocardial Injury in Rats. Cardiovasc Toxicol. 2015 Jul;15(3):250-60. doi: 10.1007/s12012-014-9292-9. PMID: 25420456.
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http://krishi.icar.gov.in/jspui/handle/123456789/77565
 
Language English
 
Relation Not Available;
 
Publisher springer sciences